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首页> 外文期刊>Evidence-based complementary and alternative medicine: eCAM >Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation
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Guzhi Zengsheng Zhitongwan, a Traditional Chinese Medicinal Formulation, Stimulates Chondrocyte Proliferation through Control of Multiple Genes Involved in Chondrocyte Proliferation and Differentiation

机译：中国中药配方的古筝增盛志通湾通过控制软骨细胞增殖和分化的多种基因刺激软骨细胞增殖

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摘要

Chinese materia medica (CMM) are essential components of traditional Chinese medicine, and Chinese medicinal formulas consisting of 2 or more types of CMM are widely used. These formulations have played a pivotal role in health protection and disease control for thousands of years. Guzhi Zengsheng Zhitongwan (GZZSZTW), which represents one of the Chinese medicinal formulations, has been used for several decades to treat joint diseases. However, the exact molecular mechanism underlying its efficacy in treating osteoarthritis remains to be elucidated. In the present study, we investigated the effects of GZZSZTW on primary chondrocytes. We demonstrated that GZZSZTW significantly promoted chondrocyte viability, maintained chondrocytes in a continuous proliferative state, and prevented their further differentiation. These effects were achieved by the synergistic interactions of various herbs and their active components in GZZSZTW through an increase in the expression levels of functional genes participating in chondrocyte commitment and proliferation and a decrease in the expression levels of genes involved in chondrocyte differentiation. GZZSZTW treatment also decreased the expression levels of genes that inhibited chondrocyte proliferation. Thus, this study has greatly deepened the current knowledge about the molecular effects of GZZSZTW on chondrocytes. It has also shed new light on possible strategies to further prevent and treat cartilage-related diseases by using traditional Chinese medicinal formulations.
机译：中药（CMM）是中药的必要组成部分，中药配方由2种或更多种CMM组成。这些制剂在千年来看，在健康保护和疾病控制中发挥了枢轴作用。代表中药制剂之一的古筝增盛志通湾（GZZSZTW）已被使用数十年来治疗联合疾病。然而，其治疗骨关节炎治疗骨关节炎的所需的精确分子机制仍有待阐明。在本研究中，我们研究了GZZSZTW对原发性软骨细胞的影响。我们证明GZZSZTW显着促进了软骨细胞活力，以连续增殖状态保持软骨细胞，并防止其进一步分化。通过在Gzzsztw中的同态相互作用来实现这些效果，通过增加有软骨细胞承诺和增殖的功能基因的表达水平的增加，以及有效的软骨细胞分化的基因表达水平的减少。 GZZSZTW治疗还降低了抑制软骨细胞增殖的基因的表达水平。因此，这项研究大大加深了目前关于GZZSZTW对软骨细胞的分子效应的了解。它还通过使用中药制剂进一步预防和治疗软骨相关疾病的可能策略。

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    Yao Baojin; Lu Bocheng; Gao Hongwei; Zhang Mei; Leng Xiangyang; Zhao Daqing;

  • 作者单位

    Changchun Univ Chinese Med Jilin Ginseng Acad Changchun 130117 Jilin Peoples R China;

    Changchun Univ Chinese Med Affiliated Hosp Changchun 130117 Jilin Peoples R China;

    Changchun Univ Chinese Med Affiliated Hosp Changchun 130117 Jilin Peoples R China;

    Changchun Univ Chinese Med Innovat Practice Ctr Changchun 130117 Jilin Peoples R China;

    Changchun Univ Chinese Med Affiliated Hosp Changchun 130117 Jilin Peoples R China;

    Changchun Univ Chinese Med Jilin Ginseng Acad Changchun 130117 Jilin Peoples R China;

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  • 正文语种 eng
  • 中图分类 临床医学;
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