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Moving towards improved vaccines for Toxoplasma gondii

机译：朝向改善毒素的疫苗致弓形虫

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Introduction: Toxoplasma gondii is an intracellular parasitic protozoan that infects almost all warm-blooded animals and humans, resulting in threats to public health and economic losses. Despite continuous research efforts, there are still very few effective strategies against toxoplasmosis. In the past few years, numerous vaccination experiments have been performed to control T. gondii infection. Areas covered: In this review, the authors summarize the development of T. gondii vaccines with proper adjuvants, ranging from live or live-attenuated vaccines to protein vaccines, DNA vaccines, epitope vaccines and novel vaccines. They also highlight the challenges involved in the development of T. gondii vaccines, including specific impediments and shortcomings. Expert opinion: Moving towards the development of effective vaccines against T. gondii is not only a tedious mission but also a difficult challenge. Future studies should consider new approaches and strategies for vaccine development, particularly novel vaccines and genetic adjuvants, as well as optimizing immunization protocols and evaluation criteria.
机译：简介：弓形虫是一种细胞内寄生原生动物，几乎感染了所有温血动物和人类，导致对公共卫生和经济损失的威胁。尽管采取了持续的研究努力，但仍有很少有效抗弓形虫病的策略。在过去的几年中，已经进行了许多疫苗接种实验以控制T.Gondii感染。所涵盖的地区：在本次审查中，作者总结了具有适当佐剂的T.Gondii疫苗的发展，从活衰减的疫苗，DNA疫苗，表位疫苗和新型疫苗的疫苗。他们还突出了T.Gondii疫苗发展所涉及的挑战，包括具体的障碍和缺点。专家意见：走向对T.Gondii的有效疫苗的发展不仅是一个乏味的使命，而且是一个艰难的挑战。未来的研究应考虑疫苗开发，特别是新疫苗和遗传佐剂的新方法和策略，以及优化免疫协议和评估标准。

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