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Working towards dengue as a vaccine-preventable disease: challenges and opportunities

机译：致力于登革热作为疫苗可预防的疾病：挑战和机遇

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Introduction: Dengue is an emerging viral disease that affects the human population around the globe. Recent advancements in dengue virus research have opened new avenues for the development of vaccines against dengue. The development of a vaccine against dengue is a challenging task because any of the four serotypes of dengue viruses can cause disease. The development of a dengue vaccine aims to provide balanced protection against all the serotypes. Several dengue vaccine candidates are in the developmental stages such as inactivated, live attenuated, recombinant subunit, and plasmid DNA vaccines.Area covered: The authors provide an overview of the progress made in the development of much needed dengue vaccines. The authors include their expert opinion and their perspectives for future developments.Expert opinion: Human trials of a live attenuated tetravalent chimeric vaccine have clearly demonstrated its potential as a dengue vaccine. Other vaccine candidate molecules such as DENVax, a recombinant chimeric vaccine andTetraVax, are at different stages of development at this time. The authors believe that the novel strategies for testing and improving the immune response of vaccine candidates in humans will eventually lead to the development of a successful dengue vaccine in future.
机译：简介：登革热是一种新兴的病毒疾病，影响全球人口。登革热病毒研究的最新进步开辟了新的途径，以发展疫苗对登革热。对登革热的疫苗的发展是一个具有挑战性的任务，因为登革热病毒的四种血清型中的任何一种都会引起疾病。登革热疫苗的发展旨在为所有血清型提供平衡的保护。几个登革热疫苗候选者处于发育阶段，例如灭活，活病变，重组亚基和质粒DNA疫苗。覆盖：提交人概述了在许多所需登革热疫苗的发展中取得的进展概述。作者包括他们的专家意见及其未来发展的观点。普及意见：现场病变的人工试验清楚地证明其作为登革热疫苗的潜力。其他疫苗候选分子如Denvax，重组嵌合疫苗和Tettavax，在此时在不同的发育阶段。作者认为，测试和改善人类疫苗候选人的免疫应答的新策略最终将导致未来成功的登革热疫苗的发展。

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