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The immunotherapy of Guillain-Barré syndrome

机译：Guillain-Barré综合征的免疫疗法

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Introduction: Guillain-Barr?syndrome is the most common cause of acute flaccid paralysis worldwide. Microorganisms such as Campylobacter jejuni, Cytomegalovirus, Epstein-Barr virus, Mycoplasma pneumoniae, Haemophilus influenzae and Zika virus have been linked to the disease. The most common clinical variants are acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. Plasma exchange and intravenous immunoglobulins are the standard therapy for the disease. Areas covered: research to elucidate the pathophysiology of Guillain-Barr?syndrome has led to the development of drugs directed towards new potential therapeutic targets. This review offers a comprehensive view of the current treatment based upon the physiopathology. Expert opinion: patients with Guillain-Barr?syndrome need a multidisciplinary approach, limitation to walk unaided and disability score are indicators for treatment as well as the presence of autonomic dysfunction and pain. Admission to intensive care units should be considered for those patients presenting with respiratory failure, bulbar involvement and progression of the disease. Research aimed to deciphering the pathophysiology of the disease, discovering new biomarkers and establishing algorithms of prediction of both the disease and its outcomes is warranted.
机译：简介：Guillain-Barr？综合征是全球最常见的急性皮脂瘫痪的原因。微生物如Campylobacter Jejuni，Cytomegalovirus，Epstein-Barr病毒，支原体肺炎，嗜血杆菌和Zika病毒已经与疾病有关。最常见的临床变体是急性炎症脱髓鞘的多肌病和急性运动轴突神经病变。血浆交换和静脉内免疫球蛋白是疾病的标准治疗。涵盖了地区：阐明突出的研究术语 - 巴尔的病理生理学综合征导致了针对新潜在治疗目标的药物的发展。本次审查提供了基于生理病理学的目前治疗的全面视图。专家意见：带有Guillain-Barr的患者？综合征需要多学科方法，局限性的局限性和残疾分数是治疗的指标以及自主功能障碍和疼痛的存在。应考虑患有呼吸衰竭，挥发杆参与和疾病进展的那些患者进行重症监护单位。旨在解读疾病病理生理学，发现新生物标志物和建立疾病预测的算法及其结果的研究得到了研究。

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