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首页> 外文期刊>European addiction research >Onset and Severity of Early Disruptive Behavioral Disorders in Treatment-Seeking Substance Use Disorder Patients with and without Attention-Deficit/Hyperactivity Disorder
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Onset and Severity of Early Disruptive Behavioral Disorders in Treatment-Seeking Substance Use Disorder Patients with and without Attention-Deficit/Hyperactivity Disorder

机译：早期破坏性行为障碍在寻求治疗物质的早期破坏性行为障碍的发病和严重程度使用疾病患者，无需注意缺陷/多动障碍

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Aims:This study addressed the age of onset of conduct disorder (CD) and oppositional defiant disorder (ODD) in treatment-seeking substance use disorder (SUD) patients with and without adult attention-deficit/hyperactivity disorder (ADHD) and its association with early onset of SUD.Methods:We examined data from the 2ndInternational ADHD in Substance Use Disorders Prevalence Study, including 400 adults in SUD treatment from Puerto Rico, Hungary, and Australia. ADHD, SUD, and CD/ODD were assessed with theConners Adult ADHD Diagnostic Interview for DSM-IV, theMINI International Neuropsychiatric Interview, and the K-SADS, respectively. Cox regression analyses modeled time to emergence of CD/ODD separately for SUD patients with and without adult ADHD. Linear regression models examined associations between age of onset of SUD and presence of ADHD and adjusted for sex, age, and country. To assess the mediating role of CD/ODD on the association of ADHD with onset of SUD, adjusted regression models were estimated.Results:Treatment-seeking SUD patients with ADHD presented an earlier onset of CD/ODD compared with those without ADHD. CD/ODD symptom loads were higher among the SUD and ADHD group. Age of first substance use and SUD were significantly earlier in SUD patients with ADHD, and these findings remained significant after adjustment for demographics and coexisting CD/ODD.Conclusions:ADHD is associated with earlier onset of SUD as well as with an earlier onset of more frequent and more severe disruptive behavioral disorders. These findings may inform preventive interventions to mitigate adverse consequences of ADHD.
机译：目的：本研究涉及进行的导尿（CD）和对抗缺陷障碍（奇数）在寻求药物使用障碍（SUD）患者的患者的疾病（CD）和反对缺陷障碍（奇数）患者的年龄及没有成人注意力/多动障碍（ADHD）及其与其联系Sud.Methods早期发作ADHD，SUD和CD / ODD分别评估了DSM-IV，THEMINI INTERNATIONAL Neuropscaistric访谈和K-SADS的THECONNERS ADD ADLD诊断访谈。 Cox回归分析为抑制患者的抑制时间为CD /奇数，抑菌患者，没有成人ADHD。线性回归模型检查了苏打突发年龄和ADHD的存在与性别，年龄和国家的年龄。为了评估CD /奇数在ADHD与SUD开始关联的介质作用，估计调整后的回归模型。结果：寻求治疗抑菌患者ADHD患者与没有ADHD的人相比，CD / Odd的早期发作。 SUD和ADHD组中的CD /奇数症状负载较高。第一次物质使用和sud的年龄在苏打患者中显着提前患有ADHD患者，并且在调整人口统计和共存CD /奇数后，这些发现仍然显着。结论：ADHD与早期的SUD发作以及更早的发病相关联经常和更严重的破坏性行为障碍。这些调查结果可能会通知预防性干预，以减轻ADHD的不利后果。

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