• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes to cells : >Rapid turnover of transcription factor Rim101 confirms a flexible adaptation mechanism against environmental stress inSaccharomyces cerevisiae
【24h】

Rapid turnover of transcription factor Rim101 confirms a flexible adaptation mechanism against environmental stress inSaccharomyces cerevisiae

机译：转录因子RIM101的快速营业额确认了对环境压力脑膜酿酒酵母的灵活适应机制

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Saccharomyces cerevisiaecells activate the Rim101 pathway to adapt to alkaline and salt stresses. On activation of this pathway, the transcription factor Rim101 undergoes proteolytic activation and regulates the expression of responsive genes. We found Rim101 to be a short-lived protein with a half-life of approximately 15 min. Its rapid turnover was supposedly mediated by the ubiquitin-proteasome system. Excess accumulation of the processed active Rim101 through its over-expression conferred tolerance to both alkaline and salt stresses in yeast cells; in contrast, it had detrimental effects under cadmium stress condition. Cadmium ion inhibited proteolytic activation of Rim101, implying reciprocal interaction between the Rim101 pathway and cadmium stress. Our results showed yeast cells to be equipped with two protective systems to prevent overaccumulation of the processed active Rim101; Rim101 processing is inhibited when Rim101 level is high, and turnover of processed Rim101 is accelerated when it is abundant. Collectively, the results confirmed the flexible aspect of stress response in yeast cell; the cells not only prevent excess activation of one stress-responsive pathway but also facilitate its attenuation to cope with other environmental stresses.
机译：Saccharomyces Cerevisiaecells激活RIM101途径以适应碱性和盐胁迫。在该途径的激活上，转录因子RIM101经历蛋白水解活化并调节响应基因的表达。我们发现RIM101是一个短暂的蛋白质，半衰期约为15分钟。它的快速营业速度应该由泛素 - 蛋白酶体系介导。通过其过度表达通过其过度表达赋予酵母细胞中碱性和盐胁迫的过度积累;相比之下，它对镉胁迫条件下有不利影响。镉离子抑制RIM101的蛋白水解活化，暗示RIM101途径与镉胁迫之间的相互作用。我们的结果表明，酵母细胞配备有两个保护系统，以防止加工的活性RIM101过度累计;当RIM101级别高时，RIM101处理被禁止，并且当它充足时加速了处理的RIM101的转换。总的来说，结果证实了酵母细胞中应力反应的灵活方面;细胞不仅防止过量激活一个应激响应途径，而且促进其衰减以应对其他环境应力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号