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首页> 外文期刊>Genomics >lncRNA SNHG16 promotes glioma tumorigenicity through miR-373/EGFR axis by activating PI3K/AKT pathway
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lncRNA SNHG16 promotes glioma tumorigenicity through miR-373/EGFR axis by activating PI3K/AKT pathway

机译：通过激活PI3K / AKT途径，LNCRNA SnHG16通过MiR-373 / EGFR轴促进胶质瘤肿瘤性度

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摘要

Glioma is one of the most common and aggressive malignant primary brain tumor with invariably poor 5-year survival rates. Because of the high recurrence rate and mortality rate, effective therapies for glioma are still weak. Recently, several studies has been proved that long non-coding RNAs (lncRNAs) have been identified to play regulatory mediators in the tumorigenesis of glioma. Nevertheless, the role of lncRNAs and their downstream transcripts are still elusive in the progression of glioma. Small nucleolar RNA host gene 16 (SNHG16), a newly identified lncRNA, has been verified to be up-regulated in human malignant carcinomas. In the present study, we confirmed that lncRNA SNHG16 was highly expressed in glioma and may exert oncogenic function as a competing endogenous RNA (ceRNA) to regulate EGFR by sponging of miR-373-3p through activating PI3K/AKT pathway, which providing a new insight of the regulatory network of lncRNA SNHG16 in the development of glioma.
机译：胶质瘤是最常见而激进的恶性原发性脑肿瘤之一，5年生存率总是贫困。 由于高复发率和死亡率，胶质瘤的有效疗法仍然薄弱。 最近，已经证明了几项研究已经鉴定了长期的非编码RNA（LNCRNA）在胶质瘤的肿瘤瘤中发挥调节介质。 然而，LNCRNA和他们的下游成绩单的作用仍然难以妨碍胶质瘤的进展。 在人恶性癌中，已经验证了新鉴定的LNCRNA的小核聚核桃RNA宿主基因16（SNHG16）。 在本研究中，我们证实LNCRNA SnHG16在胶质瘤中高度表达，可以作为竞争内源性RNA（CERNA）施加致癌功能，以通过激活PI3K / AKT途径来调节EGFR，从而提供新的 LNCRNA SNHG16监管网络在胶质瘤发育中的洞察力。

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  • 来源
    《Genomics》 |2020年第1期|共9页
  • 作者

    Zhou Xiang-Yang; Liu Hong; Ding Zheng-Bin; Xi Hai-Peng; Wang Guang-Wei;

  • 作者单位

    Univ South China Dept Neurosurg Affiliated Hosp 1 69 Chuanshan Rd Hengyang 421001 Hunan;

    Univ South China Dept Neurosurg Affiliated Hosp 1 69 Chuanshan Rd Hengyang 421001 Hunan;

    Univ South China Dept Neurosurg Affiliated Hosp 1 69 Chuanshan Rd Hengyang 421001 Hunan;

    Univ South China Dept Neurosurg Affiliated Hosp 1 69 Chuanshan Rd Hengyang 421001 Hunan;

    Univ South China Dept Neurosurg Affiliated Hosp 1 69 Chuanshan Rd Hengyang 421001 Hunan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学遗传学;
  • 关键词

    Glioma; lncRNA SNHG16; miR-373; EGFR;

    机译：胶质瘤;lncrana snhg16;mir-373;egfr;

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