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首页> 外文期刊>Genomics >Stromal interaction molecule 1 promotes tumor growth in Esophageal squamous cell carcinoma
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Stromal interaction molecule 1 promotes tumor growth in Esophageal squamous cell carcinoma

机译：基质相互作用分子1促进食管鳞状细胞癌中的肿瘤生长

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Esophageal squamous cell carcinoma (ESCC) is a disease with poor prognosis which urgently is in need of effective prognostic marker. To discover novel prognostic protein marker for ESCC, we applied a high-throughput monoclonal antibody microarray to compare tumor and adjacent non-tumor tissues from ESCC patients. Antibody #ESmAb270 was consistent higher expressed in tumors and it was identified via mass spectrometry to be stromal interaction molecule 1 (STIM1). STIM1 H scores in tumor tissues were significantly up-regulated in esophageal tumor tissues compared to non-tumor tissues in 105 ESCC patients. We also observed that high STIM1 expression was correlated with advanced tumor grade and poor prognosis of ESCC. In addition, attenuation of STIM1 by siRNA or chemical inhibitors significantly inhibited cell viability and migration of ESCC cells. Evidence from high-throughput monoclonal antibody microarray, IHC microarray with associated survival data and functional analysis show that STIM1 is an unfavorable prognostic biomarker in ESCC.
机译：食管鳞状细胞癌（ESCC）是一种患有差，预后差的疾病，迫切需要有效的预后标志物。为了发现ESCC的新预后蛋白标记，我们应用了高通量单克隆抗体微阵列以比较来自ESCC患者的肿瘤和邻近的非肿瘤组织。抗体＃ESMAB270在肿瘤中表达较高，通过质谱法鉴定为基质相互作用分子1（STIM1）。与105名ESCC患者的非肿瘤组织相比，肿瘤组织中的肿瘤组织中的STIM1 H分数在食管肿瘤组织中显着上调。我们还观察到，高精度1表达与先进的肿瘤级和ESCC预后不良相关。此外，siRNA或化学抑制剂的STIC1的衰减显着抑制了ESCC细胞的细胞活力和迁移。来自高通量单克隆抗体微阵列的证据，具有相关存活数据和功能分析的IHC微阵列表明，STIM1是ESCC中不利的预后生物标志物。

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