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首页> 外文期刊>Genomics >Acquisition of social behavior in mammalian lineages is related with duplication events of FPR genes
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Acquisition of social behavior in mammalian lineages is related with duplication events of FPR genes

机译：收购哺乳动物谱系中的社会行为与FPR基因的重复事件有关

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Formyl peptide receptors (FPRs) were firstly detected in immune cells where they act as key mediators of leukocyte chemotaxis, promoting the host defense against pathogens. Recently, three paralogs were reported in Homo sapiens (FPR1-3) and seven paralogs in Mus musculus (FPR1, FPRrs1-4, FPRrs6 and FPRrs7), but information from other mammalian lineages is scarce, including ambiguities in the current nomenclature system (e.g. absence of an orthologous relation between human and mouse FPR3). Here, we explored the FPR gene repertoire across 175 mammalian genomes using integrative phylogenetic and synteny analyses to describe the evolutionary history of FPRs in all mammalian orders. FPRs present a well conserved synteny but showed dynamic episodes of duplication events specific to several mammalian orders (Chiroptera, Perissodactyla, Primates and Rodentia), with up to 11 paralogs in some cases. Despite FPRs could be expressed in a panoply of tissues, there is a suggestion that they maintain an exclusive immunological function. However, we observed that species with social behavior have higher repertoire of FPRs in contrast with species with solitary lifestyle. Such evidence suggests a strict relationship between the optimization of the immunological system (by FPR duplication patterns) and the mammalian social behavior.
机译：首先在免疫细胞中检测到甲酰肽受体（FPRS），其中它们作为白细胞趋化性的关键介质，促进对抗病原体的宿主防御。最近，在HOMO sapiens（FPR1-3）中报道了三个副蛋白酶和血液中的七个常规蛋虫（FPR1，FPRRS1-4，FPRRS6和FPRRS7），但来自其他哺乳动物谱系的信息是稀缺的，包括当前命名系统中的歧义（例如，没有人和小鼠FPR3之间的正交关系。在这里，我们探讨了使用整合系统发育和联合分析来描述所有哺乳动物订单中FPRS进化史的FPR基因曲目。 FPRS呈现出良好的储蓄联合症，但显示出对几种哺乳动物订单（Chiroptera，Perissodactyla，灵气和啮齿动物）的动态发作，在某些情况下最多11个常规蛋白酶。尽管FPRS可以在组织的蓬松症中表达，但有一个建议，它们保持独家免疫功能。然而，我们观察到具有社会行为的物种与具有孤独的生活方式的物种相比，具有更高的FPRS曲目。这些证据表明，免疫系统的优化（FPR复制模式）和哺乳动物社会行为之间的严格关系。

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