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Functional annotation of the genome unravels probiotic potential of Bacillus coagulans HS243

机译：基因组的功能诠释芽孢杆菌HS243的益生菌潜力

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摘要

Spore forming Bacillus species are widely used as probiotics for human dietary supplements and in animal feeds. However, information on genetic basis of their probiotic action is obscure. Therefore, the present investigation was undertaken to elucidate probiotic traits of B. coagulans HS243 through its genome analysis. Genome mining revealed the presence of an arsenal of marker genes attributed to genuine probiotic traits. In silico analysis of HS243 genome revealed the presence of multi subunit ATPases, ADI pathway genes, chologlycine hydrolase, adhesion proteins for surviving and colonizing harsh gastric transit. HS243 genome harbored vitamin and essential amino acid biosynthetic genes, suggesting the use of HS243 as a nutrient supplement. Bacteriocin producing genes highlighted the disease preventing potential of HS243. Thus, this work established that HS243 possessed the genetic repertoire required for surviving harsh gastric transit and conferring health benefits to the host which were further validated by wet lab evidences.
机译：孢子形成芽孢杆菌广泛用作人类膳食补充剂和动物饲料的益生菌。但是，有关其益生菌作用的遗传基础的信息是模糊的。因此，通过其基因组分析进行了本研究以阐明B. CoAGulans HS243的益生菌特征。基因组采矿揭示了归因于真正益生菌性状的标记基因的阿森纳。在HS243基因组的硅分析中，揭示了多亚基ATP酶的存在，ADI途径基因，哲后华水解酶，粘附蛋白，用于存活和殖民的刺激性胃过境。 HS243基因组患者患有维生素和必需氨基酸生物合成基因，表明使用HS243作为营养素补充剂。细菌素产生基因强调了疾病预防HS243的潜力。因此，这项工作确立了HS243拥有存活刺激性胃部过境所需的遗传曲目，并赋予主体的健康益处，该主持人通过湿实验证据进一步验证。

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  • 来源
    《Genomics》 |2019年第4期|共9页
  • 作者

    Kapse N. G.; Engineer A. S.; Gowdaman V; Wagh S.; Dhakephalkar P. K.;

  • 作者单位

    MACS Agharkar Res Inst Bioenergy Grp GG Agarkar Rd Pune 411004 Maharashtra India;

    MACS Agharkar Res Inst Bioenergy Grp GG Agarkar Rd Pune 411004 Maharashtra India;

    MACS Agharkar Res Inst Bioenergy Grp GG Agarkar Rd Pune 411004 Maharashtra India;

    Hi Tech BioSci India Ltd Res &

    Dev Ctr Plot 6 &

    8 Ambadvet Ind Estate PO Paud Pune 412108;

    MACS Agharkar Res Inst Bioenergy Grp GG Agarkar Rd Pune 411004 Maharashtra India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学遗传学;
  • 关键词

    Genome mining; Probiotics; Bacillus coagulans;

    机译：基因组矿业;益生菌;芽孢杆菌凝固素;

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