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Gene Golden Age paradox and its partial solution

机译：基因黄金时代悖论及其部分解决方案

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The prevalence of purifying selection in the nature suggests that larger organisms bear a higher number of slightly deleterious mutations because of smaller populations and therefore weaker selection. In this work redistribution of purifying selection in favor of information genes, pathways and processes was found in primates compared with treeshrew and rodents on the ground of genome-wide analysis. The genes which are more favored in primates belong mainly to regulation of gene expression and development, in treeshrew and rodents, to metabolism, transport, energetics, reproduction and olfaction. The former occur predominantly in the nucleus, the latter, in the cytoplasm and membranes. Thus, although purifying selection is on average weaker in the primates, it is stronger concentrated on the "information technology" of life (regulation of gene expression and development). Increased accuracy of information processes probably allows escaping "error catastrophes" in spite of more complex organization, larger body size and higher longevity.
机译：本质上纯化选择的患病率表明，由于较小的人口，较大的生物体具有更高数量的略微有害的突变，因此选择较弱。在这种作品中，重新分布纯化选择的选择，这些选择在基因组分析的基因分析的基础上与Treeshrew和啮齿动物相比，在灵长类动物中发现了途径和过程。更加青睐的基因主要是对基因表达和发展的调节，在TreeshRew和啮齿动物中，代谢，运输，能量学，繁殖和嗅觉。前者主要发生在细胞核和膜中的核中。因此，尽管在灵长类动物中净化选择是平均较弱的，但它浓缩浓缩的生命“信息技术”（对基因表达和发育的调节）。提高信息流程的准确性可能允许逃离“错误灾难”，尽管是更复杂的组织，体积较大，寿命更高。

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