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Identification of prognostic signatures associated with long-term overall survival of thyroid cancer patients based on a competing endogenous RNA network

机译：基于竞争内源性RNA网络鉴定与甲状腺癌患者长期整体存活相关的预后签名

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摘要

Competing endogenous RNAs (ceRNAs) are considered as transcripts that can regulate each other at post-transcription level by competing for shared miRNAs. Considering the key roles of lncRNAs acting as ceRNAs in progression of solid tumors, to develop prognostic signatures in thyroid cancer (THCA), patients with corresponding clinical data were selected and two ceRNA networks were constructed using online databases. Two prognostic signatures (Lnc5m4 and Lnc2mi1m2) were found to be more efficient in predicting long-term survival of THCA patients. However, the high-risk score of Lnc2mi1m2 was not an independent factor.The risk score of Lnc5m4 was able to effectively stratify patients in stage III-IV into low- and high-risk groups, and also could predict poor prognosis of patients in stage III-IV. In conclusion, these findings indicate that Lnc5m4 is a novel prognostic signature for predicting long-term overall survival of THCA patients, which could provide a new approach to lncRNA research in THCA progression.
机译：竞争内源性RNA（CERNAS）被认为是通过竞争共享miRNA的转录后水平在转录后调节的转录物。考虑到LNCRNA作为CENRNAS在实体肿瘤的进展中的关键作用，在甲状腺癌（THCA）中发育预后签名，选择了临床数据的患者，并使用在线数据库构建了两个Cerna网络。发现两个预后签名（LNC5M4和LNC2MI1M2）在预测THCA患者的长期存活方面更有效。然而，LNC2MI1M2的高风险得分不是一个独立的因素。LNC5M4的风险得分能够在III-IV阶段将患者分析为低风险的群体，并且还可以预测阶段患者预后不良III-IV。总之，这些研究结果表明，LNC5M4是一种新的预后签名，用于预测THCA患者的长期整体存活，这可以为THCA进展中的LNCRNA研究提供新的方法。

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