Is this the real time for genomics?

GuarnacciaM.; GentileG.; AlessiE.; SchneiderC.; PetraliaS.; CavallaroS.

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Is this the real time for genomics?

机译：这是基因组学的实时吗？

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摘要

In the last decades, molecular biology has moved from gene-by-gene analysis to more complex studies using a genome-wide scale. Thanks to high-throughput genomic technologies, such as microarrays and next-generation sequencing, a huge amount of information has been generated, expanding our knowledge on the genetic basis of various diseases. Although some of this information could be transferred to clinical diagnostics, the technologies available are not suitable for this purpose. In this review, we will discuss the drawbacks associated with the use of traditional DNA microarrays in diagnostics, pointing out emerging platforms that could overcome these obstacles and offer a more reproducible, qualitative and quantitative multigenic analysis. New miniaturized and automated devices, called Lab-on-Chip, begin to integrate PCR and microarray on the same platform, offering integrated sample-to-result systems. The introduction of this kind of innovative devices may facilitate the transition of genome-based tests into clinical routine.

机译：在过去的几十年中，分子生物学已经从基因分析到更复杂的研究使用基因组尺度移动。由于高通量基因组技术，如微阵列和下一代测序，已经产生了大量信息，从而扩展了我们对各种疾病的遗传基础的知识。尽管这些信息中的一些可以转移到临床诊断，但可用的技术不适合此目的。在本文中，我们将讨论与诊断中使用传统DNA微阵列相关的缺点，指出可以克服这些障碍的新兴平台，并提供更可重复的，定性和定量的多群分析。新型小型化和自动化设备称为实验室，开始在同一平台上集成PCR和MicroArray，提供集成的样本到结果系统。这种创新设备的引入可以促进基于基于基于基于基于基于基于基于基于基于基于基于基于临床常规的试验。

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来源
《Genomics》 |2014年第3期|共6页
作者
GuarnacciaM.; GentileG.; AlessiE.; SchneiderC.; PetraliaS.; CavallaroS.;
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作者单位

Functional Genomics Center Institute of Neurological Sciences Italian National Research Council;

Functional Genomics Center Institute of Neurological Sciences Italian National Research Council;

Analog MEMS and Sensor Group - HealthCare Business Development Unit STMicroelectronics Stradale;

National Laboratory of the Interuniversity Consortium for Biotechnology Area Science Park;

Analog MEMS and Sensor Group - HealthCare Business Development Unit STMicroelectronics Stradale;

Functional Genomics Center Institute of Neurological Sciences Italian National Research Council;

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原文格式 PDF
正文语种 eng
中图分类医学遗传学;
关键词
Diagnostics; Genome-based tests; Lab-on-Chip; Next-generation sequencing; Point-of-Care; Real-time microarray;

机译：诊断;基于基于基于基于基于基于基于基于的测试;芯片上的;下一代测序;关注点;实时微阵列;

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Is this the real time for genomics?

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