• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genomics >Characterize the relationship between essential and TATA-containing genes for S. cerevisiae by network topologies in the perturbation sensitivity network
【24h】

Characterize the relationship between essential and TATA-containing genes for S. cerevisiae by network topologies in the perturbation sensitivity network

机译：在扰动灵敏度网络中通过网络拓扑结构表征S. Cerevisiae的必要性和塔塔基因之间的关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Essential genes are those that are indispensable for the survival and propagation of an organism. TATA-containing genes are associated with responses to various stresses and are highly regulated. Although both essential genes and TATA genes are very important in the function of biological systems, their relationship remains unclear because they have typically been researched independently. In this study, to investigate the relationship between essential genes and TATA genes, S. cerevisiae genes were classified as: essential TATA-containing, nonessential TATA-containing, essential non-TATA, and non-essential non-TATA genes. Network-based methods were applied to analyze these four gene categories in the S. cerevisiae perturbation sensitivity (PS) network, which was created from the transcriptional profiling of hundreds of different gene disruptions. All of the topological properties were found to be statistically discriminative among the four gene categories, and the non-essential TATA-containing genes had the most important roles in the yeast PS network. (C) 2016 Elsevier Inc. All rights reserved.
机译：基因是那些对于生物体的存活和繁殖是必不可少的。含塔塔基因与对各种应力的反应相关，并且受到高度调节的。尽管在生物系统的功能中，它们的必要基因和塔塔基因都非常重要，但它们的关系仍不清楚，因为它们通常已独立研究。在这项研究中，研究基因和塔塔基因之间的关系，S.Cereiaia基因被归类为：含项含塔塔，含有塔塔，必需的非塔塔和非必要的非塔塔基因。应用基于网络的方法来分析S.Cerevisiae扰动敏感性（PS）网络中的这四种基因类别，该网络是从数百种不同基因破坏的转录分析中创建的。发现所有拓扑性质在四个基因类别中存在统计学上判别，并且含非必需的塔塔基因具有酵母PS网络中最重要的作用。 （c）2016年Elsevier Inc.保留所有权利。

著录项

  • 来源
    《Genomics》 |2016年第4期|共7页
  • 作者

    Yang Lei; Wang Shiyuan; Zhou Meng; Chen Xiaowen; Zuo Yongchun; Lv Yingli;

  • 作者单位

    Harbin Med Univ Coll Bioinformat Sci &

    Technol Harbin 150081 Peoples R China;

    Harbin Med Univ Coll Bioinformat Sci &

    Technol Harbin 150081 Peoples R China;

    Harbin Med Univ Coll Bioinformat Sci &

    Technol Harbin 150081 Peoples R China;

    Harbin Med Univ Coll Bioinformat Sci &

    Technol Harbin 150081 Peoples R China;

    Inner Mongolia Univ Minist Educ Key Lab Mammalian Reprod Biol &

    Biotechnol Hohhot 010021;

    Harbin Med Univ Coll Bioinformat Sci &

    Technol Harbin 150081 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医学遗传学;
  • 关键词

    Yeast; Graph theory; Excess retention; Statistical test;

    机译：酵母;图论;过度保留;统计测试;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号