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首页> 外文期刊>Genomics >MicroRNA profiling in the bursae of Marek's disease virus-infected resistant and susceptible chicken lines
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MicroRNA profiling in the bursae of Marek's disease virus-infected resistant and susceptible chicken lines

机译：Microrna剖面在Marek疾病病毒感染抗性和易感鸡排水中

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摘要

Marek's disease (MD) is a lymphoproliferative disease of domestic chickens caused by a cell-associated oncogenic alpha-herpesvirus, Marek's disease virus (MDV). Clinical signs of MD include bursal/thymic atrophy, neurologic disorders, and T cell lymphomas. MiRNAs play key roles in regulation of gene expression by targeting translational suppression or mRNA degradation. MDV encodes miRNAs that are associated with viral pathogenicity and oncogenesis. In this study, we performed miRNA sequencing in the bursal tissues, non-tumorous but viralinduced atrophied lymphoid organ, from control and infected MD-resistant and susceptible chickens at 21 days post infection. In addition to some known miRNAs, a minimum of 300 novel miRNAs were identified in each group that mapped to the chicken genome with no sequence homology to existing miRNAs in chicken miRbase. Comparative analysis identified 54 deferentially expressed miRNAs between the chicken lines that might shed light on underlying mechanism of bursal atrophy and resistance or susceptibility to MD.
机译：Marek的疾病（MD）是由细胞相关的癌症α-卵卵巢，MAREK疾病病毒（MDV）引起的淋巴抑制性疾病。 MD的临床迹象包括Bursal /胸腺萎缩，神经系统障碍和T细胞淋巴瘤。 MiRNA通过靶向平移抑制或mRNA降解来扮演基因表达调节的关键作用。 MDV编码与病毒致病性和肿瘤发生相关的miRNA。在这项研究中，我们在感染后21天，在Bursal组织，非肿瘤但病毒诱导的萎缩淋巴管器官中进行了miRNA测序，从对照和感染的MD抗性和易感鸡。除了一些已知的miRNA之外，在将至少300种新的miRNA中鉴定在映射到鸡基因组的每组中，没有向鸡miRBase中的现有miRNA没有序列同源性。对比分析确定了54次递递培养的miRNA，在鸡豆株中可能脱落的Bursal萎缩和抗性或对MD的抗性或易感性的潜在机制。

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