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首页> 外文期刊>Gut microbes. >Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis
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Prenatal androgen exposure causes hypertension and gut microbiota dysbiosis

机译：产前雄激素暴露会导致高血压和肠道微生物症失育症

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Background: Conditions of excess androgen in women, such as polycystic ovary syndrome (PCOS), often exhibit intergenerational transmission. One way in which the risk for PCOS may be increased in daughters of affected women is through exposure to elevated androgens in utero. Hyperandrogenemic conditions have serious health consequences, including increased risk for hypertension and cardiovascular disease. Recently, gut dysbiosis has been found to induce hypertension in rats, such that blood pressure can be normalized through fecal microbial transplant. Therefore, we hypothesized that the hypertension seen in PCOS has early origins in gut dysbiosis caused by in utero exposure to excess androgen. We investigated this hypothesis with a model of prenatal androgen (PNA) exposure and maternal hyperandrogenemia by single-injection of testosterone cypionate or sesame oil vehicle (VEH) to pregnant dams in late gestation. We then completed a gut microbiota and cardiometabolic profile of the adult female offspring.
机译：背景：妇女多余雄激素的病症，如多囊卵巢综合征（PCOS），通常表现出代际透射。在受影响的女性的女儿中可能会增加PCOS风险的一种方法是通过暴露于子宫内升高的雌激素。高腺发生条件具有严重的健康后果，包括增加高血压和心血管疾病的风险。最近，已发现肠道脱泻症诱导大鼠的高血压，使血压可以通过粪便微生物移植归一化。因此，我们假设PCOS中的高血压在UTERO暴露于过量雄激素中引起的肠道脱泻性早期。我们通过单次注射睾酮含有碳酸酮碳酸酯或芝麻油载体（VEL）到晚期妊娠中的孕坝，用产前雄激素（PNA）暴露和母体高原血症模型来调查这一假设。然后，我们完成了成年女性后代的肠道微生物群和心脏素质概况。

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