Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye

Patel Roshni; Zhu Meifang; Robertson Danielle M.

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Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye

机译：移位IGF轴：人体泪液的年龄相关的下降IGF-1与干眼症的临床迹象相关

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Objective: The human corneal epithelium expresses both the insulin-like growth factor type 1 receptor (IGF-1R) and the IGF-1R/insulin receptor (INSR) hybrid. Despite the previous identification of IGF-1 in human tear fluid, little is known regarding the regulation of IGF-1 in tear fluid and its role in corneal epithelial homeostasis. In the present study, we investigated the impact of biological parameters on the concentration of human tear levels of IGF-1.

机译：目的：人角膜上皮表达胰岛素样生长因子1型受体（IGF-1R）和IGF-1R /胰岛素受体（INSR）杂种。尽管先前鉴定了人类泪液中的IGF-1，但对于撕裂液中IGF-1的调节毫无吻，其在角膜上皮稳态中的作用。在本研究中，我们研究了生物学参数对IGF-1的人撕裂水平浓度的影响。

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《Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society》 |2018年第2018期|共5页
作者
Patel Roshni; Zhu Meifang; Robertson Danielle M.;
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作者单位

UT Southwestern Dept Ophthalmol Dallas TX USA;

UT Southwestern Dept Ophthalmol Dallas TX USA;

UT Southwestern Dept Ophthalmol Dallas TX USA;

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原文格式 PDF
正文语种 eng
中图分类 R34;
关键词
Tears; IGF-1; Dry eye; Aging;

机译：泪水;IGF-1;干眼;老化;

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1. Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye [J] . Patel Roshni, Zhu Meifang, Robertson Danielle M. Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society . 2018,第期

机译：移位IGF轴：人体泪液的年龄相关的下降IGF-1与干眼症的临床迹象相关
2. Age-related variations of human tear meniscus and diagnosis of dry eye with Fourier-domain anterior segment optical coherence tomography. [J] . Qiu X, Gong L, Sun X, Cornea . 2011,第5期

机译：年龄相关的人类泪液半月板变异和干眼的傅立叶域前节光学相干断层扫描诊断。
3. ??-3 Tear Film Lipids Correlate With Clinical Measures of Dry Eye [J] . Scott D. Walter, Karsten Gronert, Allison L. McClellan, Investigative ophthalmology & visual science . 2016,第6期

机译：??-3泪膜脂质与干眼症的临床措施相关
4. Examination of in vivo tear film stability after eye blink and eye drying [C] . Dorota H. Szczesna, Zbigniew Kulas, Henryk T. Kasprzak, Conference on Biophotonics: Optics in Life Science . 2007

机译：眼睛眨眼后的体内撕裂薄膜稳定性
5. The Development of a Validated Clinically Meaningful Endpoint for the Evaluation of Tear Film Stability as a Measure of Ocular Surface Protection for Use in the Diagnosis and Evaluation of Dry Eye Disease. [D] . Abelson, Richard. 2012

机译：开发用于泪膜稳定性评估的临床上有意义的终点，作为眼表保护措施，用于干眼病的诊断和评估。
6. Shifting the IGF-axis: an age-related decline in human tear IGF-1 correlates with clinical signs of dry eye [O] . Roshni Patel, Meifang Zhu, Danielle M. Robertson -1

机译：改变IGF轴：与年龄相关的人类泪液下降IGF-1与干眼症的临床体征相关
7. Effects of Punctal Occlusion on Clinical Signs and Symptoms and on Tear Cytokine Levels in Patients with Dry Eye [O] . Tong Louis, Beuerman Roger, Simonyi Susan, 2016

机译：泪点闭塞对干眼患者临床体征和症状以及泪液细胞因子水平的影响

Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye

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