...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society >First report on persistent remission of acromegaly after withdrawal of long-term pegvisomant monotherapy
【24h】

First report on persistent remission of acromegaly after withdrawal of long-term pegvisomant monotherapy

机译：戒断长期PEG素单药治疗后终止后患者持续缓解的第一报告

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The GH-receptor antagonist pegvisomant (PEG) reduces peripheral IGF-1 synthesis and is used to treat acromegaly patients resistant or intolerant to somatostatin analogues (SSA). Medical therapy is generally life-long in patients with acromegaly, since disease remission is very uncommon after SSA discontinuation and has never been reported after PEG withdrawal. Here, we report for the first time the cases of two acromegaly patients treated with PEG monotherapy for many years because of resistance to SSA, who persistently maintained normal serum IGF-1 levels after PEG withdrawal. The first patient autonomously discontinued PEG treatment after 8 years, while in the second case we stopped the treatment after 11 years, because slight hypertransaminasemia occurred. After PEG discontinuation, in both cases IGF-1 values remained persistently normal and GH during OGTT regularly suppressed. To date, both patients are still in remission. Therefore, we suggest that PEG could exert unknown antitumoral effects in pituitary tumor cells and that long-term PEG treatment can induce acromegaly remission in some patients.
机译：GH-受体拮抗剂PEG血征（PEG）减少了外周IGF-1合成，用于治疗患者抗性或不耐生物抑制素类似物（SSA）的患者。医疗疗法通常是患者患者的终生物，因为在SSA停止后疾病缓解是非常罕见的，并且在PEG撤回后从未报告过。在这里，我们首次报告了两种患者治疗PEG单药治疗的患者，因为对SSA的抗性抗性，在PEG戒断后持续保持正常的血清IGF-1水平。第一个患者在8年后自主停止的PEG治疗，而在第二种情况下我们在11年后停止治疗，因为发生轻微的超胰岛素血症。在PEG停止后，在两种情况下，IGF-1值保持持续正常，在OGTT期间持续抑制。迄今为止，两名患者仍处于缓解情况。因此，我们建议PEG可以在垂体肿瘤细胞中发挥未知的抗肿瘤作用，并且长期PEG治疗可以在一些患者中诱导烦恼的缓解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号