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Regional variation of human pancreatic islets dimension and its impact on beta cells in Indian population

机译：人胰岛含量尺寸的区域变异及其对印度人群β细胞的影响

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Background & objectives: Islet of Langerhans, the endocrine pancreas plays a significant role in glucose metabolism. Obesity and insulin resistance are the major factors responsible for beta cell dysfunction. Asian Indian population has increased susceptibility to diabetes in spite of having lower BMI. The morphology of islets plays a significant role in beta cell function. The present study was designed for better understanding the morphology, composition and distribution of islets in different parts of the pancreas and its impact on beta cell proportion. Methods: We observed islet morphology and beta cell area proportion by Large-scale computer-assisted analysis in 20 adult human pancreases in non-diabetic Indian population. Immunohistochemical staining with anti-synaptophysin and anti-insulin antibody was used to detect islet and beta cells respectively. Whole slide images were analyzed using ImageJ software. Results: Endocrine proportion were heterogeneously increasing from head to tail with maximum islet and beta cell distribution in the tail region. Larger islets were predominately confined to the tail region. The islets in Indian population were relatively smaller in size, but they have more beta cells (20%) when compared to American population. Interpretation & conclusions: The beta cells of larger islets are functionally more active than the smaller islets via paracrine effect. Thus, reduction in the number of larger islets may be one of the probable reasons for increased susceptibility of Indians to diabetes even at lower BMI. Knowledge about the regional distribution of islets will help the surgeons to preserve the islet rich regions during surgery.
机译：背景与目标：兰氏菌岛的胰岛，内分泌胰腺在葡萄糖代谢中发挥着重要作用。肥胖和胰岛素抵抗是对β细胞功能障碍的主要因素。尽管BMI较低，亚洲印度人口对糖尿病的敏感性增加了态度。胰岛的形态在β细胞功能中发挥着重要作用。本研究旨在更好地理解胰腺的不同部位的胰岛的形态，组成和分布及其对β细胞比例的影响。方法：在非糖尿病印度人群体中，观察到20例成年人类胰腺分析的大规模计算机辅助分析，观察到胰岛素形态和β细胞区比例。用抗突触甘油和抗胰岛素抗体染色免疫组织化学染色分别检测胰岛和β细胞。使用imagej软件分析整个幻灯片图像。结果：内分泌比例从头到尾与尾部区域中的最大胰岛和β电池分布均外增加。较大的胰岛主要限制在尾部区域。与美国人口相比，印度人群中的胰岛相对较小，但它们有更多的β细胞（20％）。解释和结论：较大胰岛的β细胞通过旁碱效应的较小胰岛功能更活跃。因此，较大胰岛的数量的减少可以是即使在较低的BMI下也可能是增加印地安人对糖尿病的易感性的可能性之一。关于岛屿区域分布的知识将有助于外科医生在手术期间保留富有的富群地区。

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