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首页> 外文期刊>Glia >YAP Functions as a Mechanotransducer in Oligodendrocyte Morphogenesis and Maturation
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YAP Functions as a Mechanotransducer in Oligodendrocyte Morphogenesis and Maturation

机译：yap用作oligodendrocyte形态发生和成熟的机制助理器

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摘要

Oligodendrocytes (OLs) are myelinating cells of the central nervous system. Recent studies have shown that mechanical factors influence various cell properties. Mechanical stimuli can be transduced into intracellular biochemical signals through mechanosensors and intracellular mechanotransducers, such as YAP. However, the molecular mechanisms underlying mechanical regulation of OLs by YAP remain unknown. We found that OL morphology and interactions between OLs and neuronal axons were affected by knocking down YAP. Mechanical stretching of OL precursor cells induced nuclear YAP accumulation and assembly of focal adhesion, key platforms for mechanotransduction. Shear stress decreased the number of OL processes, whereas a dominant-negative form of YAP suppressed these effects. To investigate the roles of YAP in postnatal OLs in vivo, we constructed a novel YAP knock-in mouse and found that in vivo overexpression of YAP widely affected OL maturation. These results indicate that YAP regulates OL morphology and maturation in response to mechanical factors.
机译：oligodendrocytes（OLS）是中枢神经系统的髓鞘细胞。最近的研究表明，机械因素影响各种细胞性质。通过机械传感器和细胞内机械转换器可以将机械刺激转换成细胞内生物化学信号，例如yap。然而，yap的ols的机械调节下面的分子机制仍然未知。我们发现OLS和神经元轴突之间的形态和相互作用受到敲击yap的影响。 OL前体细胞的机械拉伸诱导核YAP积聚和局部粘附组装，机械调整的关键平台。剪切应力降低了OL过程的数量，而yap的主要负片抑制了这些效果。为了探讨YAP在体内产后OLS的作用，我们构建了一种新的YAP敲击小鼠，发现在VIVO过表达的YAP受到广泛影响的OL成熟。这些结果表明，yap响应机械因素调节OL形态和成熟。

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  • 来源
    《Glia》 |2017年第2期|共15页
  • 作者

    Shimizu Takeshi; Osanai Yasuyuki; Tanaka Kenji F.; Abe Manabu; Natsume Rie; Sakimura Kenji; Ikenaka Kazuhiro;

  • 作者单位

    Natl Inst Physiol Sci Div Neurobiol &

    Bioinformat 5-1 Higashiyama Okazaki Aichi 4448787 Japan;

    Natl Inst Physiol Sci Div Neurobiol &

    Bioinformat 5-1 Higashiyama Okazaki Aichi 4448787 Japan;

    Keio Univ Sch Med Dept Neuropsychiat Tokyo 1608582 Japan;

    Niigata Univ Brain Res Inst Dept Cellular Neurobiol Niigata Japan;

    Niigata Univ Brain Res Inst Dept Cellular Neurobiol Niigata Japan;

    Niigata Univ Brain Res Inst Dept Cellular Neurobiol Niigata Japan;

    Natl Inst Physiol Sci Div Neurobiol &

    Bioinformat 5-1 Higashiyama Okazaki Aichi 4448787 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经病学与精神病学;
  • 关键词

    oligodendrocyte; YAP; mechanotransduction;

    机译：oligodendrocyte;yap;机械手术;

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