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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents
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Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents

机译：利用Rhododendron Luteum甜生物活性化合物作为酶抑制剂，抗氧化剂和抗癌剂的有价值源

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摘要

Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of 'mad honey' poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, a-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 mu g/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors.
机译：ethnobotanical证明报告了在传统的药物系统中使用杜鹃花甜味甜味（Ericaceae）。然而，R. Luteum与“疯狂蜂蜜”中毒的发生有关。在本研究中，研究了R.乙酸乙酯，甲醇和水提取物的体外抗氧化剂，酶抑制和细胞毒性。使用MTT细胞活力测定评估A549肺癌细胞系上R.的细胞毒性。此外，使用HPLC-ESI-MSN方法来阐明R. Luteum的次级代谢物谱，以建立任何结构 - 活性关系。 R.甲醇和水提取物的甲醇和水提取物具有最高的自由基清除和降低性质，而乙酸乙酯提取物显示出最高的金属螯合性能。就酶抑制而言，具有EpigallocateChin的R.花纹的甲醇和乙酸乙酯提取物是胆碱酯酶酶，A-葡糖苷酶和酪氨酸酶的活性抑制剂。水提取物引起207.2μg/ ml IC50值的A549细胞生长抑制。虽然R. Luteum由于植物中的灰白油毒素的发生而受到了很少的科学关注，但是本作作品中提出的数据显示了R. Luteum的有希望的生物活性，并突出了其作为抗氧化剂和关键酶抑制剂的潜在来源的作用。

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