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首页> 外文期刊>Food & Function >Kinetic profile and urinary excretion of phenyl-gamma-valerolactones upon consumption of cranberry: a dose-response relationship
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Kinetic profile and urinary excretion of phenyl-gamma-valerolactones upon consumption of cranberry: a dose-response relationship

机译：腓骨 - γ-丙酮酮糖尿病患者消耗蔓越莓的动力学曲线和尿排泄：剂量 - 反应关系

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Cranberries are a rich source of poly(phenols), mainly monomeric and oligomeric flavan-3-ols. However, information on the appearance of their main circulating microbial metabolites, namely phenyl-gamma-valerolactones and phenylvaleric acid, is lacking despite its relevance to understanding the health effects attributed to cranberries. The aim of this study was to evaluate the absorption, metabolism and urinary excretion of cranberry flavan-3-ols through the targeted analysis of phenyl-gamma-valerolactones and their related phenylvaleric acids, considering also their potential as biomarkers of flavan-3-ol intake and inter-individual variability in their appearance in plasma and urine. A six-arm acute crossover, randomized, double-blinded, controlled intervention trial was performed in ten healthy males who consumed a cranberry juice drink (375, 716, 1131, 1396, 1741 mg of total flavan-3-ols) or an isocaloric control drink with one-week washout. Plasma and urine were analyzed by UHPLC-ESI-QqQ-MS/MS and 22 compounds were identified. Glucuronide and sulfate conjugates of 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone were the main circulating and excreted metabolites after cranberry juice intake, with glucuronidation appearing to be the most favorable conjugation route. These compounds reached maximum plasma concentration at about 4-6 h. Plasma and urinary concentrations of the sum of the metabolites increased in relation to the amounts of cranberry flavan-3-ols provided by the drink, showing a clear and linear dose-dependent relationship and underscoring their potential as biomarkers of flavan-3-ol intake. A high inter-individual variability in circulating and urinary metabolite levels was observed and, interestingly, some subjects seemed to display a greater efficiency in metabolizing flavan-3-ols and producing phenyl-gamma-valerolactones.
机译：蔓越莓是富含聚（酚）的丰富来源，主要是单体和低聚Flavan-3-Ols。然而，关于其主要循环微生物代谢物，即苯基 - γ-戊内甲酯和苯甲酸的信息，尽管其缺乏其与理解蔓越莓归因的健康效果缺乏。本研究的目的是通过苯基 - γ-戊酮及其相关的苯甲基甲酸的靶向分析来评估蔓越莓黄烷-3- OLS的吸收，代谢和泌尿排泄，考虑到它们作为Flavan-3-Ol的生物标志物的潜力在血浆和尿液中的出现的摄入和各种变异性。在十个健康的男性中进行六臂急性交叉，随机，双盲，受控干预试验，患有蔓越莓汁饮料（375,716,1131,1396,1741mg的总氟烷-3- ols）或异蜂理用一周的冲洗控制饮料。通过UHPLC-ESI-QQQ-MS / MS分析血浆和尿液，并鉴定了22种化合物。 5-（3'，4'-DiHydroxyphenyl）-γ-戊内酯的葡萄糖醛酸和硫酸酯缀合物是蔓越莓汁摄入后的主要循环和排出的代谢物，葡萄糖醛含量显示是最有利的共轭途径。这些化合物在约4-6小时内达到最大血浆浓度。代谢物的等离子体和尿浓度与饮料提供的蔓越莓黄酮-3-醇的量增加，显示出清晰和线性的剂量依赖关系，并强调其作为Flavan-3-Ol摄入的生物标志物的潜力。观察到循环和尿代谢物水平的高间间变异性，有趣的是，一些受试者似乎在代谢黄烷-3-醇和生产苯基 - γ-丙戊烷酮中表现出更高的效率。

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    《Food & Function》 |2020年第5期|共11页
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  • 中图分类 食品工业;
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