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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >HNF1A gene p.I27L is associated with co-existing preeclampsia in gestational diabetes mellitus
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HNF1A gene p.I27L is associated with co-existing preeclampsia in gestational diabetes mellitus

机译：HNF1A Gene P.I27L与妊娠期糖尿病中的共存预坦克敏有关

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The association of the FTO gene and HNF1 alpha gene on gestational diabetes mellitus (GDM) and preeclampsia remains unclear. This is the first study to examine whether HNF1 alpha gene and FTO gene were associated with having GDM and preeclampsia in Turkish women. Healthy pregnant women (n = 101) and women with GDM (n = 169) were included. GDM was divided into two groups as GDM-only (n = 90) and GDM-preeclampsia (n = 79). Genotyping of HNF1 alpha gene p.I27L, p.A98V, and p.S487N, and FTO gene rs9939609 SNPs were performed using RT-PCR. The frequency of p.S487N, p.A98V, and FTO genotype were similar between the groups (p > .05). p.I27L GG-wild, GT, and TT genotype were 56.5%, 36.6%, and 6.9% in controls; 40.0%, 51.1%, and 8.9% in GDM-only; and 26.6%, 51.9%, and 21.5% in GDM-preeclampsia (p = .034). TT and GT genotype was more frequent in GDM-preeclampsia than in controls (p < .05). GT genotype was increased in GDM-only compared with controls (p < .05). TT genotype was more frequent in GDM-preeclampsia than in GDM-only (p < .05). p.I27L TT genotype was independently associated with increased blood pressure (BP) and urinary protein. p.I27L TT genotype was associated with increased preeclampsia risk in patients with GDM by increasing BP and urinary protein.
机译：FTO基因和HNF1α基因对妊娠期糖尿病（GDM）和预胰岛素的关联尚不清楚。这是第一次检查HNF1α基因和FTO基因是否与在土耳其女性中具有GDM和预坦克敏相关的研究。包括健康的孕妇（N = 101）和GDM（n = 169）的女性。将GDM分为两组，仅为GDM-POST（n = 90）和GDM-PRECLAMPSIA（n = 79）。使用RT-PCR进行HNF1α基因P.I27L，P.A98V和P.S487N的基因分型，以及FTO GeneR9939609 SNP。 P.S487N，P.A98V和FTO基因型的频率在基团之间相似（P> .05）。 P.I27L GG-Wild，GT和TT基因型为对照组的56.5％，36.6％和6.9％;仅限GDM的40.0％，51.1％和8.9％; GDM-Preclampsia的26.6％，51.9％和21.5％（p = .034）。 TT和GT基因型在GDM-PREECLAMPSIA中比对照（P <.05）更频繁。仅与对照（P <0.05）相比，GT基因型在GDM中增加。 TT基因型在GDM-PREECLAMPSIA中比仅在GDM-PRECLAMPSIA中更频繁（P <.05）。 P.I27L TT基因型与增加的血压（BP）和泌尿蛋白单独相关。 P.I27L TT基因型与GDM患者通过增加BP和泌尿蛋白增加了预坦克敏风险。

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