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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Effects of ospemifene on vaginal epithelium of post-menopausal women
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Effects of ospemifene on vaginal epithelium of post-menopausal women

机译：OSPemene对绝经后妇女阴道上皮的影响

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摘要

Ospemifene is a selective estrogen receptor modulator used for the treatment of vulvo-vaginal atrophy (VVA) in post-menopausal women. No direct evidence of its effects on histological features of the human vagina has been reported. To evaluate the effects of ospemifene on histological parameters, glycogen content, proliferation, and estrogen receptor expression (ER) of vaginal epithelium in post-menopausal women. Thirty-two post-menopausal women undergoing surgical procedures were enrolled. Sixteen subjects taking ospemifene at the time of inclusion (OSP) were compared to 16 subjects not taking any hormone (CTL). Vaginal biopsies were taken from the proximal and distal vaginal wall during surgery to evaluate histology, Ki-67 and ER expression. OSP group showed thicker vaginal epithelium (34964 vs. 245 +/- 53m, p<.001), higher proliferation index (212 +/- 47 vs. 127 +/- 28 Ki-67(+) cells/mm, p<.001), higher epithelial (27.3 +/- 3.1 vs. 20.6 +/- 2.9 score, p<.001) and stromal (26.6 +/- 4.9 vs. 20.6 +/- 2.6 score, p<.001) ER expression when compared to the CTL group. In postmenopausal women affected by VVA, 1 month intake of ospemifene is associated with an increased maturation, and ER expression of the vaginal mucosa. These changes may partially explain the improvement of symptoms of vaginal atrophy reported with this drug.
机译：OSPemifene是一种选择性雌激素受体调节剂，用于治疗绝经后妇女的外阴阴道萎缩（VVA）。没有报道没有直接证据其对人类阴道的组织学特征的影响。奥斯莫芬丁烯对绝经后妇女的阴道上皮细胞性参数，糖原含量，增殖和雌激素受体表达（ER）的影响。招收了302名营业术后妇女。将包含（OSP）的osphemifene采用osphemifene的十六个受试者与16个受试者进行比较，未服用任何激素（CTL）。在手术期间从近端和远端阴道壁取出阴道活组织检查，以评估组织学，KI-67和ER表达。 OSP组显示阴道上皮更厚（34964 vs.245 +/- 53M，P <.001），增殖指数较高（212 +/- 47 vs.127 +/- 28 ki-67（+）细胞/ mm，p < .001），高上皮（27.3 +/- 3.1与20.6 +/- 2.9得分，P <.001）和基质（26.6 +/- 4.9与20.6 +/- 2.6得分，P <.001）ER表达式与CTL组相比。在受VVA影响的绝经后妇女中，1个月的奥斯莫芬肾上腺素的摄入量与阴道粘膜的成熟增加和ER表达有关。这些变化可能部分解释了这种药物报告的阴道萎缩症状的改善。

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