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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice
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Diminished ovarian reserve induced by chronic unpredictable stress in C57BL/6 mice

机译：C57BL / 6小鼠慢性不可预测应力诱导的卵巢储备减少

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Chronic psychological stress has been considered to be a remarkable contributor to diminished ovarian reserve (DOR). However, there is a lack of a psychological stress-induced DOR animal model. We aim to validate the effects of an 8-week chronic unpredictable stress (CUS) paradigm on the ovarian reserve and reproductive hormone secretion of C57BL/6 mice. We found that after an 8-week CUS exposure, the numbers of primordial and preantral follicles and corpus luteum were significantly decreased in CUS model mice. Model mice also presented higher serum follicle-stimulating hormone, corticosterone levels and lower luteinizing hormone, estradiol, testosterone, anti-Mullerian hormone levels compared to those of control mice. Furthermore, we found that FSH receptor and AMH proteins were downregulated in model mouse ovaries. Although a significant litter size difference between the two groups was not found, the ovarian reserve remained significantly lower in the model group 6 weeks after CUS exposure. These results validated the hypothesis that the 8-week CUS paradigm that we adopted could induce the DOR phenotype in C57BL/6 mice and probably had a long-term adverse effect on ovarian reserve. Therefore, our results indicate that we have successfully established an animal model of psychological stress-induced DOR that can be used for further study.
机译：慢性心理压力被认为是卵巢储备减少（DOR）的贡献者。然而，缺乏心理应激诱导的DOR动物模型。我们的目标是验证8周的慢性不可预测的压力（CUS）范式对C57BL / 6小鼠的卵巢储备和生殖激素分泌的影响。我们发现，在8周的CUS暴露后，CUS模型小鼠的原始和预瓣卵泡和语料树胶的数量显着降低。模型小鼠还呈现出更高的血清卵泡刺激激素，皮质酮水平和低丁黄激素，雌二醇，睾酮，抗Mullerian激素水平与对照小鼠相比。此外，我们发现FSH受体和AMH蛋白在模型小鼠卵巢中下调。虽然未发现两组之间的显着凋落物尺寸差异，但在CUS暴露后6周内，卵巢储备仍然显着降低。这些结果验证了我们采用的8周CU范例的假设可以诱导C57BL / 6小鼠中的DOR表型，并且可能对卵巢储备产生了长期的不利影响。因此，我们的结果表明，我们已成功建立了可以用于进一步研究的心理应激诱导的DOR的动物模型。

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