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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Prediction value of anti-Mullerian hormone (AMH) serum levels and antral follicle count (AFC) in hormonal contraceptive (HC) users and non-HC users undergoing IVF-PGD treatment
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Prediction value of anti-Mullerian hormone (AMH) serum levels and antral follicle count (AFC) in hormonal contraceptive (HC) users and non-HC users undergoing IVF-PGD treatment

机译：抗Mullerian激素（AMH）血清水平和嗜睡卵泡计数（AFC）的预测值在激素避孕药（HC）用户和IVF-PGD治疗中的非HC用户

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Use of hormone contraceptives (HC) is very popular in the reproductive age and, therefore, evaluation of ovarian reserve would be a useful tool to accurately evaluate the reproductive potential in HC users. We conducted a retrospective cohort study of 41 HC users compared to 57 non-HC users undergoing IVF-preimplantation genetic diagnosis (PGD) aiming to evaluate the effect of HC on the levels of anti-Mullerian hormone (AMH), small (2-5mm), large (6-10mm) and total antral follicle count (AFC) and the ability of these markers to predict IVF outcome. Significant differences in large AFC (p=0.04) and ovarian volume (p0.0001) were seen, however, there were no significant differences in small and total AFC or in serum AMH and FSH levels. Oocyte number significantly correlated with AMH and total AFC in HC users (p0.001) while in non-HC users these correlations were weaker. In HC users, the significant predictors of achieving6 and18 oocytes were AFC (ROC-AUC; 0.958, p=0.001 and 0.883, p=0.001) and AMH (ROC-AUC-0.858, p=0.01 and 0.878, p=0.001), respectively. The predictive values were less significant in non-HC users. These findings are important in women treated for PGD, in ovum donors and for assessing the fertility prognosis in women using HC and wishing to postpone pregnancy.
机译：使用激素避孕药（HC）在生殖年龄非常受欢迎，因此，卵巢储备的评估将是准确评估HC用户中生殖潜力的有用工具。我们对41例HC用户进行了回顾性的队列研究，而旨在评估HC对抗Mullerian激素（AMH）水平的影响，小（2-5mm） ），大（6-10mm）和总嗜烟卵泡计数（AFC）以及这些标志物预测IVF结果的能力。然而，观察大AFC（P = 0.04）和卵巢体积（P <0.0001）的显着差异，但小和总AFC或血清AMH和FSH水平没有显着差异。在非HC用户中，与AMH和总AFC在非HC用户中显着相关的卵母细胞数与非HC用户在非HC用户中，这些相关性较弱。在HC用户中，实现＆ 6和 18个卵母细胞的显着预测因子是AFC（Roc-AUC; 0.958，P = 0.001和0.883，P = 0.001）和AMH（Roc-AUC-0.858，P = 0.01和0.878，P分别= 0.001）。预测值在非HC用户中不太重要。这些发现在卵子供体中对PGD治疗的妇女是重要的，并用于评估使用HC的女性的生育预后，并希望推迟怀孕。

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