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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The stimulation of the vaginal immune system with short-term administration of a vaginal gel containing fraction of Propionibacterium acnes, hyaluronic acid and polycarbophil is efficacious in vaginal infections dependent on disorders in the vaginal ecosystem
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The stimulation of the vaginal immune system with short-term administration of a vaginal gel containing fraction of Propionibacterium acnes, hyaluronic acid and polycarbophil is efficacious in vaginal infections dependent on disorders in the vaginal ecosystem

机译：阴道免疫系统的刺激短期施用含有丙酸杆菌的阴道凝胶，透明质酸和聚氨基粒细胞的阴道凝胶，阴道感染依赖于阴道生态系统中的疾病是有效的

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The vaginal immune system (VIS) is the first defense against antigens recognized as foreign. Substances capable of locally activating the VIS could be a valid strategy to treat vulvo-vaginal infections (Wl), caused by changes in the vaginal ecosystem, such as bacterial vaginosis (BV), vulvo-vaginal candidiasis (CA), and mixed vaginitis (MV). Bacterial lysates, obtained by crushing bacterial cultures, exert immuno-modulatory activities. The parietal fraction from Propionibacterium acnes is a patent of Depofarma (MoglianoVeneto, Italy). The preparation that associates such fraction to hyaluronic acid and polycarbophil is a registered trademark, commercially available in Italy as vaginal gel, Immunovag. The study aimed to evaluate whether a 5-day-treatment with Immunovag improves the symptoms and signs of Wl, in 60 women with Gardnerella vaginalis (GV), 154 with CA, 95 with MV, diagnosed with vulvar vaginal swab (WS), and in 283 with BV, diagnosed with the Amsel criteria. At the end of the treatment (visit 2), the symptoms and signs of Wl disappeared in a significant number of subjects (x~2p<-02 vs pre-treatment) in all Wl groups, and their intensity was significantly (p<.0002) reduced in the subjects in which they were still present. Immunovag represents a valid treatment of Wl induced by changes in the vaginal ecosystem.
机译：阴道免疫系统（VIS）是对抗原的第一次防御被认为是外国人。能够局部激活VI的物质可以是治疗外阴阴道感染（WL）的有效策略，由阴道生态系统（如细菌性阴道病（BV），外阴阴道念珠菌（BV），外阴阴道念珠菌（CA）和混合阴道炎（ MV）。通过破碎细菌培养物获得的细菌裂解物，施加免疫调节活性。来自丙杆菌Acnes的Paretal馏分是Depofarma的专利（意大利Moglianoveneto）。将这种份额与透明质酸和聚氨基酚联合的制剂是注册商标，在意大利商业上可用作阴道凝胶，免疫凝胶，免疫凝胶。该研究旨在评估Immunovag的5日治疗是否改善了WL的症状和迹象，其中60名WARDNELLA VAGINARIS（GV），154名，含有MV的CA，95，诊断出外阴阴道拭子（WS），以及在283年，BV诊断为AMSEL标准。在治疗结束时（参见2），WL的症状和迹象在所有WL组中的大量受试者（X〜2P <-02 vs预处理）中消失，它们的强度显着（P <。 0002）减少了它们仍然存在的受试者。 Immunovag代表了阴道生态系统变化诱导的WL的有效治疗。

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