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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Inter-cycle and inter-observer variability of the antral follicle count in routine clinical practice
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Inter-cycle and inter-observer variability of the antral follicle count in routine clinical practice

机译：血管卵泡计数的阶段周期和观察者间变异性常规临床实践

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摘要

Antral follicle count (AFC) is a reliable predictor of ovarian response to stimulation and its inter-cycle and inter-observer variability has been extensively studied on in vitro fertilization (IVF), mostly in highly selected populations within studies not originally designed for this purpose. In this retrospective cohort study, we assess the inter-cycle variation of AFC in a setting similar to that of the daily practice. We included only patients undergoing mild stimulation for intrauterine insemination (IUI). One hundred and forty-eight patients had two (62 patients, group A), three (49 patients, group B) or four (37 patients, group C) IUI cycles and AFC was measured on early follicular phase of each cycle by one of the members of the medical team within daily practice. Intra-class correlation coefficients were used to estimate variability. Inter-cycle variability rendered ICCs above 0.70 in all groups improving along with the number of cycles [Group A ICC 0.78 (95%CI 0.66-0.86), Group B ICC 0.87 (95%CI 0.80-0.92) and Group C ICC 0.91 (95%CI 0.85-0.95)]. Inter-observer variability showed a high degree of concordance with ICCs above 0.95. We provide the closest approximation to real inter-cycle and inter-observer AFC variability expected in routine clinical practice.
机译：Antral卵泡计数（AFC）是卵巢反应的可靠预测因子，对刺激的血液反应，并且其周期和观察者间变异性已经广泛研究了体外施肥（IVF），主要是在最初为此目的设计的研究中的高度选择的人群中。在此回顾性队列研究中，我们评估AFC在类似于日常实践的环境中的循环间变化。我们仅包括对宫内授精（IUI）进行温和刺激​​的患者。一百四十八名患者有两种（62名患者，A组），三（49名患者，B组）或四（37名患者，C组）IUI循环和AFC在每个周期的早期滤泡阶段上测量医疗团队的成员在日常练习中。类内相关系数用于估计变异性。循环间变异性在所有基团上以高于0.70的ICC，以及循环次数[ICC 0.78（95％CI 0.66-0.86），B组ICC 0.87（95％CI 0.80-0.92）和C型ICC 0.91组（ 95％CI 0.85-0.95）]。观察者间变异性显示出高于0.95的ICC的高度一致性。我们为实际循环和观察者间临床实践中的观察者间AFC间可变性提供最近的近似。

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