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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Vaginal cytokines do not correlate with postmenopausal vulvovaginal symptoms
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Vaginal cytokines do not correlate with postmenopausal vulvovaginal symptoms

机译：阴道细胞因子与绝经后脓毒症症状无关

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Objectives: Exploratory pilot study to determine the correlation between postmenopausal vulvovaginal symptoms and vaginal cytokine levels. Methods: Postmenopausal women [n-34) not using menopausal hormone therapy and presenting with or without symptoms of vulvovaginal irritation were screened. Each participant underwent a vaginal examination and screening for vaginitis. A cervicovaginal lavage (CVL) with sterile saline and a peripheral blood sample were obtained. Main outcome measures were assessed by Luminex? X-map method on the Bio-Plex? platform. Main outcome measures were cervicovaginal and serum interleukin (IL)-4, IL-5, IL-10, IL-12, IL-13, TNF-alpha, GM-CSF, MIP-1-alpha and RANTES level. Cervicovaginale cytokines were adjusted to total protein concentration [pg/ meg protein]. Results: Twenty-six postmenopausal women were enrolled (symptomatic: n=15; asymptomatic: n = 11). There were no significant differences between groups: age, age at menopause, vaginal pH and all CVL and serum cytokines (IL-4, IL-5, IL-10, IL-12, IL-13, TNF-a, GM-CSF, MIP-1 -alpha and RANTES). GM-CSF was the most abundant vaginal cytokine (symptomatic: 146.5 ±165.6 pg/meg protein; asymptomatic: 146.0 ±173.5 pg/meg protein; p = 0.99). Conclusions: Postmenopausal vulvovaginal symptoms did not correlate with vaginal inflammatory marker. There was no difference in serum or CVL cytokines between symptomatic and asymptomatic postmenopasual women. Vaginal symptoms after menopause are not related to the vaginal cytokine changes associated with loss of estrogen.
机译：目的：探索性试验研究，以确定绝经后脓肿症状与阴道细胞因子水平之间的相关性。方法：筛选未使用绝经期妇女[N-34）[N-34），筛选未使用未经维多韦刺激刺激的症状或没有症状。每个参与者都经过阴道检查和筛查阴道炎。获得具有无菌盐水和外周血样品的宫颈植物灌洗（CV1）。 Luminex评估主要结果措施？ Bio-Plex上的X-MAP方法？平台。主要结果测量是宫颈病毒和血清白细胞介素（IL）-4，IL-5，IL-10，IL-12，IL-13，TNF-α，GM-CSF，MIP-1-α和RANTES水平。将宫颈病毒因子调节至全蛋白质浓度[pg / meg蛋白]。结果：预计二十六个绝经后妇女（症状：N = 15;无症状：N = 11）。群体之间没有显着差异：年龄，绝经年龄，阴道pH和所有CV1和血清细胞因子（IL-4，IL-5，IL-10，IL-12，IL-13，TNF-A，GM-CSF ，mip-1 -alpha和rantes）。 GM-CSF是阴道细胞因子最丰富的（症状：146.5±165.6页PG / MEG蛋白;无症状：146.0±173.5 pg / meg蛋白; p = 0.99）。结论：绝经后脓肿症状与阴道炎症标志物无关。症状和无症状后医生妇女之间的血清或CVL细胞因子没有差异。绝经后的阴道症状与与雌激素丧失相关的阴道细胞因子变化无关。

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