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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Protective effects of sildenafil citrate administration on cisplatin-induced ovarian damage in rats
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Protective effects of sildenafil citrate administration on cisplatin-induced ovarian damage in rats

机译：西地那非柠檬酸盐给药对大鼠顺铂诱导卵巢损伤的保护作用

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The aim of this study is to evaluate the effects of sildenafil citrate on cisplatin-induced ovarian toxicity. Thirty-two female rats were divided into four groups. Group 1: saline control; group 2: cisplatin; group 3: sildenafil citrate; and group 4: cisplatin plus sildenafil citrate group. In groups 2 and 4, the rats were injected with 5 mg/kg cisplatin intraperitoneally (i.p.). In groups 3 and 4, the rats were injected with 1.4 mg/kg sildenafil citrate i.p. The ovaries were removed two weeks later in all groups. Histopathologic examination, follicle counting and classification were performed. The expression of anti-Mullerian hormone (AMH) was detected immunohisto-chemically in the ovarian tissues. Sildenafil alleviated cisplatin-induced histopathological changes in the ovarian tissue. Primordial, secondary and tertiary follicles were diminished in group 2 compared with group 1 (p<0.05). Pretreatment with sildenafil citrate preserved primordial follicle count in group 4 compared with group 2, and the difference was statistically significant (p<0.05). According to our results, immunoreactivity intensity of AMH was lower in group 2 compared with group 1 (92.4±3.97 versus 88.8 + 1.77) but not significantly, whereas immunoreactivity intensity of AMH was higher in group 4 compared with group 2 (88.8 ±1.77 versus 94.1 ±2.36; p< 0.05). Our results demonstrated that pretreatment with sildenafil citrate is beneficial for protecting the ovaries from cisplatin-induced damage. Sildenafil citrate can be a choice for fertility preservation.
机译：本研究的目的是评估西地那非柠檬酸酯对顺铂诱导的卵巢毒性的影响。三十二个雌性大鼠分为四组。第1组：盐水控制;第2组：顺铂;第3组：西地那非柠檬酸盐;和第4组：顺铂加Sildenafil柠檬酸盐组。在第2和4组中，将大鼠腹膜内注射5mg / kg顺铂（I.p.）。在第3和第4组中，将大鼠注射1.4mg / kg Sildenafil柠檬酸盐I.P.卵巢在所有群体后两周后被清除。进行组织病理学检查，卵泡计数和分类。在卵巢组织中检测免疫组化学检测抗Mullerian激素（AMH）的表达。 Sildenafil缓解了顺铂诱导的卵巢组织中的组织病理学变化。与第1组相比，第2组降低了原始，二次和三级卵泡（P <0.05）。与第4组柠檬酸西地那非保存原始卵泡计数的预处理与第2组相比，差异有统计学意义（P <0.05）。根据我们的结果，与第1组（92.4±3.97与88.8 + 1.77）相比，第2组的AMH的免疫反应强度较低，但不显着，而第4组的AMH的免疫反应强度较高（88.8±1.77与94.1±2.36; p <0.05）。我们的研究结果表明，西地那非柠檬酸盐的预处理有利于保护卵巢免受顺铂诱导的损伤。西地那非柠檬酸盐可以是生育保存的选择。

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