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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Investigation on the association of occupational stress with risk of polycystic ovary syndrome and mediating effects of HOMA-IR
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Investigation on the association of occupational stress with risk of polycystic ovary syndrome and mediating effects of HOMA-IR

机译：具有多囊卵巢综合征风险的职业胁迫与HOMA-IR介导效应的调查

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We aimed to evaluate the association between occupational stress and PCOS risk in a Chinese population and whether insulin resistance mediates the association. A total of 366 patients with PCOS and 325 controls were included in this study. Three logistic regression analyzes were applied in statistical analysis. In the first logistic regression analysis, the occupational stress significantly influenced development of PCOS (cumulative R~2 = 0.737). In model 2, the environmental factors cumulatively accounted for 4.2% of the variance in PCOS risk. In model 3, which contained HOMA-IR, the R~2 of HOMA-IR to PCOS risk was as high as 0.41, but the R~2 of occupational stress reduced to 0.22. HOMA-IR became the main risk factor for PCOS. SEM model showed that ORQ, PSQ and PRQ had a direct and indirect effect on PCOS, and the indirect effect was through HOMA-IR. Occupational stress has a direct and indirect relationship with PCOS, which is mediated by HOMA-IR.
机译：我们旨在评估中国人群中职业压力和PCOS风险的关联，以及胰岛素抵抗是否介导协会。 本研究共纳入了366例PCOS和325例对照。 统计分析中应用了三个逻辑回归分析。 在第一逻辑回归分析中，职业应力显着影响了PCOS的发育（累积R〜2 = 0.737）。 在2型中，环境因素累计占PCOS风险方差的4.2％。 在含有HOMA-IR的模型3中，HOMA-IR的R〜2对PCOS风险高达0.41，但职业应激的R〜2降至0.22。 HOMA-IR成为PCOS的主要风险因素。 SEM模型显示ORQ，PSQ和PRQ对PCOS的直接和间接影响，间接效应通过HOMA-IR。 职业压力与PCOS有直接和间接的关系，由HOMA-IR介导。

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