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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Polymorphisms in vitamin D receptor gene, but not vitamin D levels, are associated with polycystic ovary syndrome in Brazilian women
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Polymorphisms in vitamin D receptor gene, but not vitamin D levels, are associated with polycystic ovary syndrome in Brazilian women

机译：维生素D受体基因的多态性，但不是维生素D水平，与巴西女性的多囊卵巢综合征有关

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摘要

This study aimed to investigate the association between vitamin D (VitD) levels, polymorphisms in VDR gene (Apal, Bsml, Fokl, and Taql) and the polycystic ovary syndrome (PCOS) in a group of Brazilian women. A total of 100 patients with PCOS and 100 control women were included. The quantification of 25-hydroxyvitamin D (25(OH)D) was performed in high-performance liquid chromatography (HPLC). Polymorphisms on VDR gene were performed by PCR-RFLP. The Bsml AG genotype was more frequent in PCOS group, while the GG genotype was more frequent in the control group (p = .007). The frequency of the Taql CC genotype was higher in PCOS group, while the CT genotype was the most frequent in the control group (p = .021). Mean serum VitD levels were similar between the groups. However, there was a negative correlation between VitD levels and Ferriman-Gallwey score (p = .031, r= -.260) in the PCOS group. The Taql and Bsml polymorphisms were associated with PCOS. Moreover, VitD levels are associated with the clinical hyperandrogenism. The data suggest the role of VitD in PCOS development and its complications.
机译：该研究旨在探讨维生素D（VITD）水平，VDR基因（APAL，BSML，Fok1和TaqL）和多囊卵巢综合征（PCOS）在一群巴西女性之间的关联。共有100名PCOS和100名妇女的患者。在高效液相色谱（HPLC）中进行25-羟基vitamind（25（OH）D）的定量。通过PCR-RFLP进行VDR基因的多态性。在PCOS组中，BSML Ag基因型更频繁，而GG基因型在对照组中更频繁（p = .007）。 PCOS组的TaqL CC基因型的频率较高，而CT基因型是对照组中最常见的（p = .021）。在组之间平均血清Vitd水平相似。然而，PCOS组中的VITD水平与Ferriman-Gallwey评分（P = .031，r = -.260）之间存在负相关性。 TAQL和BSML多态性与PCOS相关联。此外，VitD水平与临床高衰老症相关。该数据表明Vitd在PCOS开发中的作用及其并发症。

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