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首页> 外文期刊>Journal of assisted reproduction and genetics >Anti-Mullerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome
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Anti-Mullerian hormone level is associated with vitamin D receptor polymorphisms in women with polycystic ovary syndrome

机译：抗Mullerian激素水平与患有多囊卵巢综合征的女性中的维生素D受体多态性有关

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ObjectiveOur study aimed to investigate the relationship between polymorphisms (Apa1, Bsm1, Fok1, and Cdx2) in the VDR gene as well as AMH and AMHR2 genes and their influence on AMH and 25(OH)D levels in PCOS women.Study designSeventy-five patients with PCOS and 23 control women were included. Serum AMH and 25(OH)D levels in patients and controls were measured by enzyme-linked immunosorbent assay (ELISA). Polymorphisms in VDR gene Fok1 C/T (rs2228587), Bsm1 A/G (rs1544410), Apa1 A/C (rs7975232), and Cdx2 A/G (rs11568820) polymorphisms as well as AMH G/T (rs10407022) and AMHR2 A/G (rs2002555) were analyzed using real-time PCR.ResultsAnalysis of the VDR Cdx2 polymorphism showed a significantly higher frequency of the homozygous GG (mutant) genotype in the PCOS group as compared with the control group (p<0.05). The analysis revealed a statistically significant correlation between the presence of FokI and ApaI polymorphisms and AMH levels in PCOS women (p<0.05). The presence of mutant genotypes (CT, TT) in the Fok1 and (CA, CC) in the Apa1 polymorphisms were associated with higher AMH level in PCOS women (p<0.05). No statistically significant correlations between AMH and AMHR2 polymorphisms and AMH level were found. Moreover, there was no correlation between AMH and 25(OH)D levels in the PCOS or in the control group.ConclusionIt seems that the elevated AMH level is associated with VDR Fokl and Apal polymorphisms, but not with 25(OH)D levels in PCOS women. Further research is needed to determine the role of VDR polymorphism in AMH level in PCOS.
机译：目的研究旨在调查VDR基因多态性（APA1，BSM1，Fok1和CDX2）与AMH和AMHR2基因的关系及其对PCOH女性的AMH和25（OH）D水平的影响及其影响.Sudy Designseventy-5包括PCOS和23妇女的患者。通过酶联免疫吸附试验（ELISA）测量患者和对照中的血清AMH和25（OH）D水平。 VDR基因Fok1 C / T（RS2228587），BSM1A / G（RS1544410），APA1 A / C（RS7975232）和CDX2 A / G（RS11568820）的多态性以及AMH G / T（RS10407022）和AMHR2 A中的多态性使用实时PCR进行分析/ g（RS2002555）。与对照组相比，VDR CDX2多态性的VDR CDX2多态性分析显示PCOS组中的纯合GG（突变体）基因型的显着较高频率（P <0.05）。该分析显示Foki和Apai多态性的存在与PCOS女性的AMH水平之间的统计学相关性（P <0.05）。在APA1多态性中FOK1和（CA，CC）中的突变基因型（CT，TT）的存在与PCOS女性的较高的AMH水平相关（P <0.05）。没有发现AMH和AMHR2多态性与AMH水平之间的统计学上显着的相关性。此外，PCOS中的AMH和25（OH）D水平之间没有相关性，或者在对照组中.Conclusionit似乎升高的AMH水平与VDR FOKL和APAL多态性相关，但不具有25（OH）D水平PCOS女性。需要进一步的研究来确定VDR多态性在PCOS中AMH水平的作用。

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