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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescents
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High dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescents

机译：高剂量维生素D补充可以改善青少年中的月经问题，痛经和经常综合征

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Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received nine high-dose vitamin D supplements (as 50,000 lU/week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in four categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (p<.001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well as decrement in pain severity of dysmenorrhea (p<.05). High dose vitamin D supplementation can reduce the prevalence of PMS and dysmenorrhea as well as has positive effects on the physical and psychological symptoms of PMS.
机译：维生素D对女性繁殖具有至关重要的作用，可能通过其对钙稳态，循环性类固醇波动或神经递质功能的影响。我们评估了维生素D补充对青少年痛经和经前综合征（PMS）的影响。在这项研究中，897名居住在Mashhad和Sabzevar，伊朗的少剂维生素D补充剂（As 50,000 Lu /周的Cholecalciferol），并随访9周。我们评估了维生素D补充在四个类别上的效果：只有PMS的人;只有痛经的个体;具有PMS和痛经和正常对象的受试者。干预后PM的患病率降至4.9％至4.8％（P <.001）。还发现类似的结果用于痛经（35.9％降至32.4％），并在PMS和痛经中的受试者中（32.7％降低25.7％）。维生素D补充剂与降低PMS的几种症状的发病率降低有关，例如腰痛和呼吸倾向以及痛经疼痛严重程度（P <.05）。高剂量维生素D补充可以降低PMS和痛经的患病率，以及对PMS的身体和心理症状具有积极影响。

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