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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Fine-particulate matter (PM2.5), a risk factor for rat gestational diabetes with altered blood glucose and pancreatic GLUT2 expression
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Fine-particulate matter (PM2.5), a risk factor for rat gestational diabetes with altered blood glucose and pancreatic GLUT2 expression

机译：细颗粒物质（PM2.5），大鼠妊娠糖尿病具有改变的血糖和胰腺Glut2表达的危险因素

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摘要

Recent studies have shown an intriguing association between air pollution and diabetic risk. This study was to investigate the impact of fine particulate matter (PM2.5) on glucose consequences and pancreas glucose transporter2 (GLUT2) expression in a gestational diabetes mellitus (GDM) rat model. GDM rats were exposed to a low PM2.5 dose during pregnancy. After exposure, interleukin-6 (IL-6) and blood routine tests (BRT) were detected. Pancreas underwent pathologic examination. The levels of pancreatic homogenate glutathione peroxidase (GSH-Px), methane dicarboxylic aldehyde (MDA) and GLUT2 were detected. There were lower maternal body weight gain and fetal weight in the PM2.5 group. Exposure to PM2.5 caused increased absorbed blastocyst number, higher blood mono-nuclear cells (PBMC), platelets and IL-6 levels. The postprandial blood glucose (PBG) was elevated at most time points after exposure. The pancreas of PM2.5 exposed rats revealed periductal inflammation under pathological examination. The pancreatic GSH-Px significantly reduced and MDA increased in exposed group. The pancreatic GLUT2 expression was decreased after PM2.5 exposure. Our study provides direct evidence that PM2.5 exposure can result in pancreatic pathological changes and glycemic consequences in GDM rats. The oxidative response and inflammation are involved in PM2.5 increased risk of pancreatic impairment and glycemic consequences.
机译：最近的研究表明了空气污染与糖尿病风险之间有趣的关联。该研究是探讨细颗粒物质（PM2.5）对妊娠期糖尿病（GDM）大鼠模型中葡萄糖后果和胰腺葡萄糖转运蛋白表达的影响。在妊娠期间将GDM大鼠暴露于低PM2.5剂量。暴露后，检测白细胞介素-6（IL-6）和血液常规测试（BRT）。胰腺接受病理检查。检测到胰腺匀浆糖硫硫氨酰硫氨酰胺（GSH-PX），甲烷二羧酸醛（MDA）和GLUT2的水平。 PM2.5组中母体体重增加和胎儿重量较低。暴露于PM2.5引起的吸收胚泡数量增加，血液单核细胞（PBMC），血小板和IL-6水平增加。暴露后最多的时间点升高了餐后血糖（PBG）。 PM2.5暴露大鼠的胰腺揭示了病理检查下的潜水炎症。胰腺GSH-PX显着降低，曝光组中的MDA增加。 PM2.5暴露后，胰腺结露表达减少。我们的研究提供了直接证据，即PM2.5暴露会导致GDM大鼠胰腺病理变化和血糖后果。氧化反应和炎症涉及PM2.5增加的胰腺损伤风险和血糖后果。

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