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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Differential expression of visfatin, leptin, stromal cell derived factor-1, endothelial nitric oxide synthase, and vascular endothelial growth factor in human leiomyomas
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Differential expression of visfatin, leptin, stromal cell derived factor-1, endothelial nitric oxide synthase, and vascular endothelial growth factor in human leiomyomas

机译：visfatin，瘦素，基质细胞衍生因子-1，内皮一氧化氮合酶和人对血管内皮生长因子的差异表达

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Aim: This study was aimed to understand expressions of the visfatin, leptin, stromal cell derived factor (SDF)-1, endothelial nitric oxide synthase (eNOS), and vascular endothelial growth factor (VEGF) in human uterine leiomyomas (UL) and normal myometrium.Method: This study investigated expression of visfatin, leptin, SDF-1, eNOS and VEGF in 23 uterine leiomyoma patients and 10 normal myometrium by RT-PCR and western blot. Messenger RNA transcripts of SDF-1, eNOS, VEGF and hypoxia inducible factor-1 (HIF-1) were analyzed according to the size of UL by real-time PCR.Results: There were no significant differences in expressions of visfatin and leptin between UL compared with normal myometrium. However, expressions of eNOS, SDF-1 and VEGF were significantly higher in both intramural and subserosal UL compared with normal myometrium. The expression of SDF1- was significantly increased in small UL (5cm) compared to the large UL (5cm), whereas the expressions of eNOS, VEGF and HIF-1 were higher in large UL than small UL.Conclusions: This study shows that expression of SDF-1, eNOS and VEGF were significantly higher in UL than myometrium with a different expression pattern according to the size of UL. However, expressions of visfatin and leptin had no significant differences between the two groups.
机译：目的：本研究旨在了解人子宫内皮（UL）和正常的人子宫（UL）和正常情况下了解人子宫（UL）和正常的缺失表达的粘霉素，瘦素，基质细胞衍生因子（SDF）-1，内皮型生长因子（VEGF）的表达Myometrium.method：本研究通过RT-PCR和Western印迹调查了23例子宫平滑肌瘤患者和10例正常Myometriual的visfatin，瘦素，SDF-1，eNOS和VEGF的表达。根据UL的大小通过实时PCR，分析了SDF-1，eNOS，VEGF和缺氧诱导因子-1（HIF-1）的信使RNA转录物（RESULTS ul与正常的myometrium相比。然而，与正常的肌肌室相比，intramural和本地UL的enos，SDF-1和VEGF的表达显着高。与大的UL（5cm）相比，小的UL（＆lt 2. 5cm）中SDF1-的表达显着增加，而ENOS，VEGF和HIF-1的表达在大的UL中比小UL.CONCLUSIONS：本研究表明根据UL的尺寸，SDF-1，eNOS和VEGF的表达比UL的肌腱显着高于Myometrium。然而，两组之间存在缺失和瘦素的表达在两组之间没有显着差异。

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