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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Ovarian steroid cell tumor as an example of severe hyperandrogenism in 45-year-old woman
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Ovarian steroid cell tumor as an example of severe hyperandrogenism in 45-year-old woman

机译：卵巢类固醇细胞肿瘤是45岁女性中严重高衰老的举例

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Approximately, 5% of ovarian tumors have hormonal activity. Steroid cell tumors (SCTs) represent about 0.1% of all ovarian tumors. They cause hyperandrogenism associated with typical virilization. In this case report, we present 45-year-old women with unmalignant ovarian SCT-producing androgens which cause severe virilization and secondary amenorrhea lasting two years. Transvaginal ultrasound, computed tomography of adrenal glands, magnetic resonance imaging of small pelvis, laboratory tests (including serum concentration of FSH, LH, testosterone (T), androstenedione (A), dehydroepiandrosterone sulfate (DHEA-S), as well as ROMA index) were performed. During hormonal evaluation, elevated concentrations of serum T - on admission 1.72 ng/ml and one month later 3.75 ng/ml (normal range 0.08-0.82 ng/ml) and A - 24.90 ng/ml (normal range 0.40-3.40 ng/ml) were found. The ROMA index was within the normal range. Enlargement of the left ovary by solid mass 56 x 43 mm was found during ultrasound examination. Based on small pelvis MRI scan and hormonal finding, patient was qualified for laparotomy. During this procedure, the left salpingo-oophorectomy with removal of the tumor was performed. The histopathological examination identified SCT. During follow-up examination, one day after surgery, we found serum testosterone levels within normal ranges - 0.74 ng/ml (normal range 0.08-0.82 ng/ml). This case shows that hormone-producing ovarian tumors are rare but very important clinical causes of severe hyperandrogenism.
机译：大约5％的卵巢肿瘤具有激素活动。类固醇细胞肿瘤（SCT）占所有卵巢肿瘤的0.1％。它们导致与典型的病毒相关的高腺激发。在本案报告中，我们展示了45岁的女性，患有非人手术卵巢SCT的雄激素，导致严重的病毒化和继发性闭经持续两年。经阴道超声波，肾上腺的计算机断层扫描，小骨盆的磁共振成像，实验室测试（包括FSH，LH，睾酮（T），Androstenione（A），脱氢硫代酮硫酸盐（DHEA-S）以及ROMA指数的血清浓度）进行了。在激素评价期间，血清浓度升高为1.72 ng / ml和一个月后3.75ng / ml（正常范围0.08-0.82ng / ml）和a - 24.90 ng / ml（正常范围0.40-3.40ng / ml ） 被找到。罗马索引在正常范围内。在超声检查期间发现通过固体质量的固体质量的左卵巢放大56×43mm。基于小骨盆MRI扫描和荷尔蒙发现，患者有资格达到剖腹手术。在此过程中，进行具有去除肿瘤的左Salpingo-Oophorectomy。组织病理学检查确定了SCT。在后续检查期间，手术后一天，我们发现正常范围内的血清睾酮水平 - 0.74ng / ml（正常范围0.08-0.82ng / ml）。这种情况表明，产生激素的卵巢肿瘤是罕见的，非常重要的临床原因严重的高衰老。

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