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首页> 外文期刊>Forensic science international >Time-dependent postmortem redistribution of butyrfentanyl and its metabolites in blood and alternative matrices in a case of butyrfentanyl intoxication
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Time-dependent postmortem redistribution of butyrfentanyl and its metabolites in blood and alternative matrices in a case of butyrfentanyl intoxication

机译：在丁福戊烷中毒的情况下，丁福戊烷基的时间依赖于抑制丁烷基及其代谢物和替代基质中的代谢物

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A fatal case of butyrfentanyl poisoning was investigated at the Zurich Institute of Forensic Medicine. At admission at the institute approx. 9 h after death (first time point, t1), femoral and heart blood (right ventricle) was collected, as well as samples from the lung, liver, kidney, spleen, muscle and adipose tissue using computed tomography (CT)-guided biopsy sampling. At autopsy (t2), samples from the same body regions were collected manually. Additionally, urine, heart blood (left ventricle), gastric content, brain samples and hair were collected. Butyrfentanyl concentrations and relative concentrations of the metabolites carboxy-, hydroxy-, nor-, and desbutyrfentanyl were determined by LC-MS/MS and LC-QTOF. At t1, butyrfentanyl concentrations were 66 ng/mL in femoral blood, 39 ng/mL in heart blood, 110 ng/g in muscle, 57 ng/g in liver, 160 ng/g in kidney, 3100 ng/g in lung, 590 ng/g in spleen and 550 ng/g in adipose tissue. At t2, butyrfentanyl concentration in urine was 1100 ng/mL, in gastric content 2000 ng/mL, in hair 11,000 pg/mg and brain concentrations ranged between 200-340 ng/g. Carboxyand hydroxybutyrfentanyl were identified as most abundant metabolites. Comparison of t1 and t2 showed a concentration increase of butyrfentanyl in femoral blood of 120%, in heart blood of 55% and a decrease in lung of 30% within 19 h. No clear concentration changes could be observed in the other matrices. Postmortem concentration changes were also observed for the metabolites. In conclusion, butyrfentanyl seems to be prone to postmortem redistribution processes and concentrations in forensic death cases should be interpreted with caution. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
机译：在苏黎世法医学研究所研究了胎儿丁烷基中毒的致命情况。在研究所的入场处约。 9小时死亡（第一次，T1），收集股骨和心脏血液（右心室），以及使用计算机断层扫描（CT）-guide活组织检查的来自肺，肝，肾，脾，肌肉和脂肪组织的样品采样。在尸检（T2）处，手动收集来自相同体积的样品。此外，收集尿液，心脏血液（左心室），胃含量，脑样品和毛发。通过LC-MS / MS和LC-QTOF测定丁福戊烷浓度和代谢物，羟基，NOR-和DESBUTFENTAN基的相对浓度。在T1时，抗替芬烷基浓度为66ng / ml在股血液中，39 ng / ml在心血中，肌肉110ng / g，肝脏中的57 ng / g，肾脏，3100ng / g在肺中，3100ng / g，在脂肪组织中脾脏和550ng / g的590 ng / g。在T2时，尿液烯基浓度在尿液中为1100ng / ml，在胃含量2000ng / ml中，在头发11,000pg / mg和脑浓度之间，介于200-340 ng / g之间。羧酸羧酸羟基丁替芬太基被鉴定为最丰富的代谢物。 T1和T2的比较显示股骨血液中丁氟苯基的浓度增加120％，心血血液为55％，肺部减少30％。在其他矩阵中不能观察到明确的浓度变化。代谢物也观察到后期浓度变化。总之，丁福芬太尼似乎容易出现后期再分布过程，并且法医死亡病例中的浓度应谨慎解释。 （c）2016 Elsevier Ireland Ltd.保留所有权利。

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