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首页> 外文期刊>Fish & Shellfish Immunology >Immunity-associated long non-coding RNA and expression in response to bacterial infection in large yellow croaker (Larimichthys crocea)
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Immunity-associated long non-coding RNA and expression in response to bacterial infection in large yellow croaker (Larimichthys crocea)

机译：免疫相关的长非编码RNA和表达响应大黄鱼中的细菌感染（Larimichthys Crocea）

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摘要

Long non-coding RNA refers to an RNA transcript of a non-coding protein with a sequence length greater than 200 bp. More and more reports indicated that lncRNA was involved in the regulation of gene expression as a signalling molecule, an inducing molecule, a leader molecule and a scaffold molecule. Previous studies have sequenced the draft genome and several transcriptome data sets for protein-coding genes of the large yellow croaker (Larimichthys crocea), but little is known about the expression and function of lncRNAs in this species. In order to obtain a catalogue of lncRNAs for this croaker, Vibrio parahaemolyticus infection challenge experiment was conducted and long non-coding RNA sequences were obtained. Using high-throughput sequencing of lncRNA, a total of 73,233 high-confidence transcripts were reconstructed in 32,726 loci, recovering most of the expressed reference transcripts, and 6473 novel expressed loci were identified. The tissue expression profile revealed that most lacunas were specifically enriched in distinct tissues. A set of 163 lncRNAs were identified as being specifically expressed in the spleen and may be involved in the immune response. It is the first time to identify specific lncRNAs in the L. crocea systematically in this croaker, aiming to benefit the future genomic study of this species.
机译：长的非编码RNA是指非编码蛋白的RNA转录物，其序列长度大于200bp。越来越多的报道表明，LNCRNA参与了基因表达的调节作为信号分子，诱导分子，领导物分子和支架分子。以前的研究对大黄鱼（Larimichthys Crocea）的蛋白质编码基因进行了对基因组草案和几种转录组数据集，但是关于该物种中LNCRNA的表达和功能几乎是众所周知的。为了获得该克罗斯克的LNCRNA目录，进行了副血糖溶血性感染攻击实验，并获得了长的非编码RNA序列。利用LNCRNA的高通量测序，共在32,726个基因座中重建了73,233种高置信转录物，恢复大部分表达的参考转录物，并鉴定了6473种新型表达的基因座。组织表达谱表明，大多数LECUNA在不同的组织中特异性富集。鉴定了一组163LNCRNA，如在脾脏中特异性表达，并且可以参与免疫应答。这是第一次系统地在该克罗斯克系统地识别L. Crocea中的特定LNCRNA，旨在使该物种的未来基因组研究受益。

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  • 来源
    《Fish & Shellfish Immunology》 |2019年第2019期|共9页
  • 作者

    Liu Xiaoxu; Li Weiye; Jiang Lihua; Lu Zhenming; Liu Minhai; Gong Li; Liu Bingjian; Liu Liqin; Yin Xiaolong;

  • 作者单位

    Zhejiang Ocean Univ Coll Marine Sci Natl Engn Res Ctr Marine Facil Aquaculture 1 Haida South Rd Zhoushan 316022 Zhejiang Peoples R China;

    Adm Ocean &

    Fisheries Zhoushan 21 Chenghe Xi Rd Zhoushan 316021 Zhejiang Peoples R China;

    Zhejiang Ocean Univ Coll Marine Sci Natl Engn Res Ctr Marine Facil Aquaculture 1 Haida South Rd Zhoushan 316022 Zhejiang Peoples R China;

    Zhejiang Ocean Univ Coll Marine Sci Natl Engn Res Ctr Marine Facil Aquaculture 1 Haida South Rd Zhoushan 316022 Zhejiang Peoples R China;

    Adm Ocean &

    Fisheries Zhoushan 21 Chenghe Xi Rd Zhoushan 316021 Zhejiang Peoples R China;

    Zhejiang Ocean Univ Coll Marine Sci Natl Engn Res Ctr Marine Facil Aquaculture 1 Haida South Rd Zhoushan 316022 Zhejiang Peoples R China;

    Zhejiang Ocean Univ Coll Marine Sci Natl Engn Res Ctr Marine Facil Aquaculture 1 Haida South Rd Zhoushan 316022 Zhejiang Peoples R China;

    Zhejiang Ocean Univ Coll Marine Sci Natl Engn Res Ctr Marine Facil Aquaculture 1 Haida South Rd Zhoushan 316022 Zhejiang Peoples R China;

    Adm Ocean &

    Fisheries Zhoushan 21 Chenghe Xi Rd Zhoushan 316021 Zhejiang Peoples R China;

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  • 正文语种 eng
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