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首页> 外文期刊>Fish & Shellfish Immunology >Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)
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Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)

机译：膳食酸曲面减少肠道免疫力和生长草鲤鱼的加重炎症（Ctenopharyngodon Idella）

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The present study explored the effects of dietary gossypol on the gut health of on-growing grass carp. The fish were fed six diets containing different levels of free gossypol (0, 121.38, 243.94, 363.89, 759.93 and 1162.06 mg/kg diet) from gossypol-acetic acid for 60 days and then challenged with Aeromonas hydrophila for 14 days. The results showed that dietary gossypol (1) could aggravate enteritis and damage the structure of intestinal epithelial cells, (2) decreased the lysozyme (LZ) and Acid phosphatase (ACP) activities, complement 3 (C3), C4 and immunoglobulin M (IgM) contents, and it down-regulated the Hepcidin (rather than distal intestine (DI)), immunoglobulin Z (IgZ), liver-expressed antimicrobial peptide (LEAP)-2B, Mucin2 and beta-defensin-1 mRNA levels in the proximal intestine (PI), mid intestine (MI) and DI, (3) up-regulated intestinal pro-inflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interferon gamma 2 (IFN-gamma 2), interleukin 1 beta (IL-1 beta), IL-6 (only in PI), IL-8 and IL-12p35 mRNA levels partly related to nuclear factor kappa B (NF-kappa B) signalling, and (4) down-regulated the mRNA levels of anti-inflammatory cytokines such as transforming growth factor (TGF)-beta 1, TGF-beta 2, interleukin 4/13A (IL-4/13A) (except IL-4/13B), IL-10 and IL-11 partly relating to target of rapamycin (TOR) signalling in the intestines of on-growing grass carp. Moreover, the dietary gossypol had no impact on the LEAP-2A, IL-12P40, IL-17D, IL-10, NF-kappa Bp52, IKK alpha and eIF4E-binding proteins 2 (4E-BP2) mRNA levels in the intestines. Finally, based on the intestinal histopathological results, enteritis morbidity, LZ activity and IgM content, the safe dose of gossypol in the diets for on-growing grass carp should be less than 103.42 mg/kg diet.
机译：本研究探讨了膳食糖屏醇对生长草鲤鱼肠道健康的影响。将鱼类喂食六个饮食，其中含有不同水平的游离型无胨（0,121.38,243.94,363.89,759.93和1162.06mg / kg饮食）从Gossypol-乙酸60天，然后用Aeromonas疏水液攻击14天。结果表明，膳食棉醇（1）可以加重肠炎，损伤肠上皮细胞的结构，（2）降低溶菌酶（LZ）和酸性磷酸酶（ACP）活性，补体3（C3），C4和免疫球蛋白M（IgM ）含量，其下调肝素（而不是远端肠（DI）），免疫球蛋白Z（IGZ），肝脏表达的抗微生物肽（LEAP）-2B，MUCIN2和β-防御蛋白-1 mRNA水平在近端肠道中（PI），中肠（MI）和DI，（3）上调肠道炎症细胞因子肿瘤坏死因子α（TNF-α），干扰素γ2（IFN-GAMMA 2），白细胞介素1β（IL-1 β），IL-6（仅在PI），IL-8和IL-12P35 mRNA水平部分与核因子Kappa B（NF-Kappa B）信号传导相关，（4）下调抗炎的mRNA水平细胞因子，例如转化生长因子（TGF）-beta 1，TGF-β2，白细胞介素4 / 13a（IL-4 / 13b）（除IL-4 / 13b之外），IL-10和IL-11部分与目标o相关F雷帕霉素（TOR）信号传导在生长的草鲤鱼的肠中。此外，膳食糖型对肠中的膳食棉酚对Leap-2a，IL-12P40，IL-17D，IKKα和EIF4E结合蛋白2（4E-BP2）mRNA水平没有影响。最后，基于肠道病理学结果，肠炎发病率，LZ活性和IgM含量，生长草鲤鱼饮食中的安全剂量的棉酚应小于103.42毫克/千克饮食。

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