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首页> 外文期刊>Fish & Shellfish Immunology >The role of infectious hematopoietic necrosis virus (IHNV) proteins in recruiting the ESCRT pathway through three ways in the host cells of fish during IHNV budding
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The role of infectious hematopoietic necrosis virus (IHNV) proteins in recruiting the ESCRT pathway through three ways in the host cells of fish during IHNV budding

机译：传染性造血坏死病毒（IHNV）蛋白在IHNV萌芽期间通过三种方式募集Escrt途径的作用

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摘要

In cytokinetic abscission, phagophore formation, and enveloped virus budding are mediated by the endosomal sorting complex required for transport (ESCRT). Many retroviruses and RNA viruses encode "late-domain" motifs that can interact with the components of the ESCRT pathway to mediate the viral assembly and budding. However, the rhabdovirus in fish has been rarely investigated. In this study, inhibition the protein expression of the ESCRT components reduces the extracellular virion production, which preliminarily indicates that the ESCRT pathway is involved in IHNV release. The respective interactions of IHNV proteins including M, G, L protein with Nedd4, Tsg101, and Alix suggest the underlying molecular mechanism by which IHNV gets access to the ESCRT pathway. These results are the first observation that rhabdovirus in fish gains access to the ESCRT pathway through three ways of interactions between viral proteins and host proteins. In addition, the results show that IHNV is released from host cells through the ESCRT pathway. Taken together, our study provides a theoretical basis for studying the budding mechanism of IHNV.
机译：在细胞内容性脱落，噬菌体形成和包膜病毒芽是由转运（Escrt）所需的内体分选复合物介导的。许多逆转录病毒和RNA病毒编码了可以与Escrt途径的组分相互作用以介导病毒组装和萌芽的“晚域”图谱。然而，鱼中的rhabdovirus很少被研究。在该研究中，抑制Escrt组分的蛋白表达减少了细胞外病毒藻植物，这初步表明Escrt途径参与了IHNV释放。 IHNV蛋白的相互作用与NEDD4，TSG101和ALIX的IHNV蛋白质的相互作用表明IHNV获得对ESCRT途径的潜在的分子机制。这些结果是首次观察，即通过三种病毒蛋白和宿主蛋白之间的三种相互作用方式获得rhabdovirus的rhabdovirus进入Escrt途径。此外，结果表明，IHNV通过ESCRT途径从宿主细胞释放。我们的研究共同参与了研究IHNV的萌芽机制的理论依据。

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  • 来源
    《Fish & Shellfish Immunology》 |2019年第2019期|共9页
  • 作者

    Chen Yaping; Li Jiahui; Zhou Ying; Feng Ying; Guan Xin; Li Dechuan; Ren Xuanyu; Gao Shuai; Huang Jinshan; Guan Xueting; Shi Wen; Liu Min;

  • 作者单位

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

    Northeast Agr Univ Coll Anim Sci &

    Technol Chang Jiang Rd 600 Harbin 150030 Heilongjiang Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 水产、渔业;
  • 关键词

    Infectious hematopoietic necrosis virus; Late-domain; ESCRT; Budding;

    机译：传染病造血坏死病毒;晚域;Escrt;萌芽;

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