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首页> 外文期刊>Frontiers in neuroendocrinology >You've got male: Sex and the microbiota-gut-brain axis across the lifespan
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You've got male: Sex and the microbiota-gut-brain axis across the lifespan

机译：你有男性：性别和微生物疱疹脑轴穿过寿命

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摘要

Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex can also influence the complexity and diversity of microbes that we harbour in our gut; and reciprocally that our gut microbes can directly and indirectly influence sex steroid hormones and central gene activation. There is a growing emphasis on the role of gastrointestinal microbiota in the maintenance of mental health and their role in the pathogenesis of disease. In this review, we introduce mechanisms by which gastrointestinal microbiota are thought to mediate positive health benefits along the gut-brain axis, we report how they may be modulated by sex, the role they play in sex steroid hormone regulation, and their sex-specific effects in various disorders relating to mental health.
机译：性是诊断和开发许多心理健康障碍，包括自闭症，精神分裂症，抑郁症，焦虑，帕金森病，多发性硬化症，厌食症和其他症状的关键因素;可能是由于性类固醇激素和遗传学的差异。最近的证据表明，性别也会影响我们在肠道中港口的微生物的复杂性和多样性;并相应地，我们的肠道微生物可以直接和间接地影响性类固醇激素和中枢基因活化。胃肠道微生菌在维持心理健康和疾病发病机制中的作用，越来越强调。在本文中，我们介绍了胃肠微生物群被认为沿着肠轴轴介导积极健康益处的机制，我们报告了它们如何通过性，他们在性类固醇调节中发挥的作用以及他们的性别特定的作用各种疾病的影响与心理健康有关。

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