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首页> 外文期刊>Gastroenterology research and practice >Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms
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Clinicopathological Features and Prognostic Factors of Colorectal Neuroendocrine Neoplasms

机译：结直肠神经内分泌肿瘤的临床病理特征及预后因素

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Background. Limited research is available regarding colorectal NENs and the prognostic factors remain controversial. Materials and Methods. A total of 68 patients with colorectal NENs were studied retrospectively. Clinical characteristics and prognosis between colonic and rectal NENs were compared. The Cox regression models were used to evaluate the predictive capacity. Results. Of the 68 colorectal NENs patients, 43 (63.2%) had rectal NENs, and 25 (36.8%) had colonic NENs. Compared with rectal NENs, colonic NENs more frequently exhibited larger tumor size (P<0.0001) and distant metastasis (P<0.0001). Colonic NENs had a worse prognosis (P=0.027), with 5-year overall survival rates of 66.7% versus 88.1%. NET, NEC, and MANEC were noted in 61.8%, 23.5%, and 14.7% of patients, respectively. Multivariate analyses revealed that tumor location was not an independent prognostic factor (P=0.081), but tumor size (P=0.037) and pathological classification (P=0.012) were independent prognostic factors. Conclusion. Significant differences exist between colonic and rectal NENs. Multivariate analysis indicated that tumor size and pathological classification were associated with prognosis. Tumor location was not an independent factor. The worse outcome of colonic NENs observed in clinical practice might be due not only to the biological differences, but also to larger tumor size in colonic NENs caused by the delayed diagnosis.
机译：背景。有限的研究是关于结直肠内部的，预后因素仍然存在争议。材料和方法。回顾性地研究了68例结直肠癌患者。比较了结肠和直肠Nens之间的临床特征和预后。 COX回归模型用于评估预测能力。结果。在68名结肠直肠非患者的患者中，43例（63.2％）具有直肠NENS，25个（36.8％）具有结肠内部。与直肠NEN相比，结肠人更常见地表现出较大的肿瘤大小（P <0.0001）和远处转移（P <0.0001）。结肠人的预后（p = 0.027），5年的总生存率为66.7％，而88.1％。净，NEC和Manec分别以61.8％，23.5％和14.7％的患者分别注意到。多变量分析显示肿瘤位置不是独立的预后因子（p = 0.081），但肿瘤大小（p = 0.037）和病理分类（p = 0.012）是独立的预后因素。结论。结肠和直肠NENS之间存在显着差异。多变量分析表明肿瘤大小和病理分类与预后有关。肿瘤位置不是一个独立的因素。在临床实践中观察到的结肠内人的较差的结果可能是由于生物差异，也可能是由于延迟诊断引起的结肠内部肿瘤大小。

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