Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures

Tyrlikova Ivana; Brazdil Milan; Rektor Ivan; Tyrlik Michal

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Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures

机译：Perampanel作为单药治疗和临床发病癫痫发作的辅助治疗，局灶性对双侧滋补克隆癫痫发作以及广义发病滋补克隆癫痫发作的辅助治疗

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Introduction: Perampanel is an antiepileptic drug approved in the USA and Europe as monotherapy and adjunctive therapy for focal onset seizures and as adjunctive therapy for generalized tonic-clonic seizures.

机译：介绍：Perampanel是美国和欧洲批准的抗癫痫药物，作为单一疗法和临界发作癫痫发作的辅助治疗，以及作为广义滋补克隆癫痫发作的辅助治疗。

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来源
《Expert review of neurotherapeutics》 |2019年第6期|共12页
作者
Tyrlikova Ivana; Brazdil Milan; Rektor Ivan; Tyrlik Michal;
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作者单位

Mid Atlantic Epilepsy &

Sleep Ctr 6410 Rockledge Dr Suite 610 Bethesda MD 20817 USA;

Masaryk Univ St Annes Univ Hosp Dept Neurol 1 Brno Epilepsy Ctr Brno Czech Republic;

Masaryk Univ St Annes Univ Hosp Dept Neurol 1 Brno Epilepsy Ctr Brno Czech Republic;

Mid Atlantic Epilepsy &

Sleep Ctr 6410 Rockledge Dr Suite 610 Bethesda MD 20817 USA;

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原文格式 PDF
正文语种 eng
中图分类神经病学与精神病学;
关键词
AMPA receptor antagonist; anti-seizure drug; adjunctive therapy; monotherapy; focal seizures; generalized tonic-clonic seizures;

机译：AMPA受体拮抗剂;抗癫痫药;辅助治疗;单药治疗;焦点癫痫发作;广义滋补克隆癫痫发作;

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1. Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures [J] . Tyrlikova Ivana, Brazdil Milan, Rektor Ivan, Expert review of neurotherapeutics . 2019,第1a6期

机译：Perampanel作为单药治疗和临床发病癫痫发作的辅助治疗，局灶性对双侧滋补克隆癫痫发作以及广义发病滋补克隆癫痫发作的辅助治疗
2. Efficacy and safety of adjunctive perampanel in patients with focal seizures or generalized tonic‐clonic seizures: Post hoc analysis of Phase II and Phase III double‐blind and open‐label extension studies in India [J] . Man M. Mehndiratta, Manoj Gulhane, Shaik A. Jabeen, Epilepsia Open . 2021,第1期

机译：临床癫痫发作或广义滋补克隆癫痫发作患者的疗效和安全性：印度II期和III阶段双盲和开放标签延伸研究的后HOC分析
3. Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to <12?years) with inadequately controlled focal seizures or generalized tonic‐clonic seizures [J] . Fogarasi Andras, Flamini Robert, Milh Mathieu, Epilepsia: Journal of the International League against Epilepsy . 2020,第1期

机译：开放标签研究，探讨儿科患者辅助妨碍妨碍患者的安全性和有效性（4至12岁），焦点癫痫发作或广义滋补克隆癫痫发作
4. Stimulation strength and focality of electroconvulsive therapy and magnetic seizure therapy in a realistic head model [C] . Lee Won Hee, Lisanby Sarah H., Laine Andrew F., Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2014

机译：逼真的头部模型中电惊厥疗法和磁惊厥疗法的刺激强度和焦点
5. Ventral Pallidum Deep Brain Stimulation Has Potent Efficacy for Generalized Tonic-Clonic Seizures in the Pentylenetetrazole Rat Model of Epilepsy [D] . Zeng, Andrew J. 2020

机译：腹侧Pallidum深脑刺激对癫痫戊酮大鼠大鼠模型中的普通滋补克隆癫痫发作具有有效的疗效
6. Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures [O] . Stephen Taylor, Catrin Tudur Smith, Paula R Williamson, -1

机译：苯巴比妥与苯妥英单药治疗部分发作和广泛发作的强直阵挛性发作
7. Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review [O] . Nolan, SJ, Marson, AG, Weston, J, 2016

机译：苯妥英钠与丙戊酸单药治疗部分发作和广义发作性强直-阵挛性发作：个体参与者数据回顾

Perampanel as monotherapy and adjunctive therapy for focal onset seizures, focal to bilateral tonic-clonic seizures and as adjunctive therapy of generalized onset tonic-clonic seizures

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