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首页> 外文期刊>Mammalian genome: official journal of the International Mammalian Genome Society >Fearful old world? A commentary on the Second International Summit on human genome editing
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Fearful old world? A commentary on the Second International Summit on human genome editing

机译：恐惧的老世界？ 对人类基因组编辑第二次国际峰会的评论

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摘要

Genome editing is revolutionising our ability to modify genomes with exquisite precision for medical and agricultural applications, and in basic research. The first International Summit on Human Genome Editing, organised jointly by the US National Academies of Sciences and Medicine, the Chinese Academy of Sciences and the UK Royal Society, was held in Washington DC at the end of 2015. Its aim was to explore scientific, legal and ethical perspectives on the prospective use of human genome editing as a therapeutic intervention in disease (so-called somatic genome editing) and as a possible intervention in human reproduction (so-called germ-line genome editing). Following that Summit, the Organising Committee had, in a press release, come to the conclusion that: It would be irresponsible to proceed with any clinical use of germ line editing unless and until (i) the relevant safety and efficacy issues have been resolved, based on appropriate understanding and balancing of risks, potential benefits and alternatives, and (ii) there is broad societal consensus about the appropriateness of the proposed application (http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=12032015a). A report from the US National Academies subsequently reiterated and developed the approach.
机译：基因组编辑正在彻底改变我们对医疗和农业应用精湛精确的改变基因组的能力，以及基础研究。美国国家科学院和英国皇家社会共同组织的人类基因组编辑的第一次国际峰会于2015年底在华盛顿特区举行。其目的是探索科学，对人类基因组编辑作为疾病治疗干预（所谓的体细胞基因组编辑）和人类繁殖的可能干预（所谓的种质基因组编辑）的法律和伦理观点。在该峰会之后，组委会在一份新闻稿中获得了结论：继续进行任何临床使用的临床编辑是不负责任的，除非（i）相关的安全和疗效问题已经解决，基于适当的理解和平衡风险，潜在的福利和替代方案，（ii）关于拟议申请的适当性有广泛的社会共识（http://www8.nationalacademies.org/onpinews/newsitem.aspx?recordid=12032015a ）。来自美国国家学院的一份报告随后重申并制定了这种方法。

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