...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Mammal research >Genome-wide investigation of microsatellite polymorphism in coding region of the giant panda (Ailuropoda melanoleuca) genome: a resource for study of phenotype diversity and abnormal traits
【24h】

Genome-wide investigation of microsatellite polymorphism in coding region of the giant panda (Ailuropoda melanoleuca) genome: a resource for study of phenotype diversity and abnormal traits

机译：基因组 - 微卫星多态性在巨大熊猫（Ailuropoda Melanoleuca）基因组中的微卫星多态性研究：一种研究表型多样性和异常性状的资源

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Repeat number variations of coding simple sequence repeats (coding SSRs) generate phenotype diversity for environmental adaptation and rapid adaptive evolution. Despite the positive potential of coding SSR mutations, the repeat variations have also been shown to cause hereditary disorders and severe diseases. However, there have been few reports on the analysis of SSR polymorphism in genome-wide coding regions. We identified 1016 coding SSRs, of which 283 SSRs (27.9%) were polymorphic with 2 to 8 alleles, using 33 re-sequenced giant panda genomes. The 283 polymorphic coding SSRs were mapped on 260 genes, which were assigned into 547 GO terms. Functional analysis of 260 genes showed that four significantly enriched pathways: thyroid hormone signaling pathway, pancreatic secretion, gastric acid secretion, and thyroid hormone synthesis, were relevant to digestion and metabolism. The comparison analysis of gene functions exhibited positive regulation of transcription, DNA-templated term (GO:0045893), the poly(A) RNA-binding term (GO:0008270), and zinc ion-binding term (GO:0044822) which were only significantly enriched in genes containing polymorphic coding SSRs. This indicates coding SSR polymorphism may be involved in binding and regulation functions that can affect the expression of their downstream genes and contribute to diverse phenotypes. Our results provide a solid foundation for further study regarding the effect of coding SSR polymorphism on the adaptation, adaptive evolution, and abnormal traits of the giant panda.
机译：重复编码简单序列重复（编码SSRS）的重复数变型生成环境适应和快速自适应进化的表型多样性。尽管编码SSR突变的积极潜力，但也已显示重复变异来引起遗传性疾病和严重疾病。然而，关于宽基因组编码区中SSR多态性的分析很少有报道。我们确定了1016个编码SSR，其中283SSR（27.9％）是具有2至8个等位基因的多态性，使用33重新测序的巨大熊猫基因组。将283个多态性编码SSR映射在260个基因上，分配成547个术语。 260个基因的功能分析表明，四种显着富集的途径：甲状腺激素信号通路，胰腺分泌，胃酸分泌和甲状腺激素合成，与消化和代谢相关。基因函数的比较分析表现出转录的正调节，DNA模板术语（GO：0045893），聚（a）RNA结合项（GO：0008270）和锌离子结合项（GO：0044822）仅在含有多态性编码SSRS的基因中显着富集。这表明编码SSR多态性可能涉及可以影响其下游基因表达并有助于不同表型的结合和调节功能。我们的结果为进一步研究了关于编码SSR多态性对巨型熊猫的适应，自适应演化和异常性状的进一步研究的坚实基础。

著录项

  • 来源
    《Mammal research》 |2019年第3期|共11页
  • 作者

    Cheng Meiling; Ren Jianying; Shen Fujun; Huang Yan; Fan Zhenxin; Price Megan; Yue Bisong; Zhang Xiuyue;

  • 作者单位

    Sichuan Univ Coll Life Sci Minist Educ Key Lab Bioresources &

    Ecoenvironm Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Coll Life Sci Minist Educ Key Lab Bioresources &

    Ecoenvironm Chengdu 610064 Sichuan Peoples R China;

    Chengdu Res Base Giant Panda Breeding Sichuan Key Lab Conservat Biol Endangered Wildlif Chengdu 610081 Sichuan Peoples R China;

    China Res &

    Conservat Ctr Giant Panda Dujiangyan 611830 Peoples R China;

    Sichuan Univ Coll Life Sci Minist Educ Key Lab Bioresources &

    Ecoenvironm Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Coll Life Sci Minist Educ Key Lab Bioresources &

    Ecoenvironm Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Coll Life Sci Sichuan Key Lab Conservat Biol Endangered Wildlif Chengdu 610064 Sichuan Peoples R China;

    Sichuan Univ Coll Life Sci Minist Educ Key Lab Bioresources &

    Ecoenvironm Chengdu 610064 Sichuan Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物学;
  • 关键词

    Ailuropoda melanoleuca; Coding SSRs; Polymorphism; Phenotype diversity;

    机译：Ailuropoda melanoleuca;编码SSRS;多态性;表型多样性;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号