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首页> 外文期刊>Medical hypotheses >Why is running a marathon like giving birth? The possible role of oxytocin in the underestimation of the memory of pain induced by labor and intense exercise
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Why is running a marathon like giving birth? The possible role of oxytocin in the underestimation of the memory of pain induced by labor and intense exercise

机译：为什么要跑一场马拉松就像分娩一样？ 催产素可能在低估劳动和强烈运动诱导的疼痛记忆中的可能作用

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摘要

Pain can be overestimated, underestimated or reported accurately at recall. The way pain is remembered seems to depend on certain factors, including the type of pain or, in other words, its cause, the context, and the meaning it has for the person suffering from it. For instance, episodes of chronic pain, as well as pain related to surgery, are often overestimated at recall. Interestingly, research shows that pain induced by parturition or marathon running is often underestimated at recall despite the fact that both are not only physically grueling but also emotionally intense experiences. However, both processes can likewise be considered positive events, as opposed to most that involve pain. On the neurophysiological level, one of the similarities between giving birth and running a marathon is the particular involvement of the oxytocin system. Oxytocin is involved both in parturition and intense exercise, for various reasons. During labor, oxytocin mediates uterine contractions, while in the case of extensive running it might be involved in the maintenance of fluid balance. It also has well documented analgesic properties and plays an important role in memory formation and recall. It has been suggested that oxytocin modulates the output of the central nucleus of the amygdala (CeA) during the fear recall. Moreover, it has been demonstrated that oxytocin can impair fear learning and influence the memory of both positive and negative emotionally salient stimuli. We propose that the reason for pain to be remembered in a more favorable light is the central action of oxytocin in the central nucleus of the amygdala, first and foremost during the encoding phase.
机译：在召回时，疼痛可以高估，低估或准确地报告。被记住的痛苦的方式似乎取决于某些因素，包括痛苦的类型，或者换句话说，其原因，背景和它为患有它的人的意义。例如，慢性疼痛的发作以及与手术相关的疼痛通常在召回时估计。有趣的是，尽管这两者不仅是身体艰苦的事实，但矿物或马拉松赛跑的痛苦往往低估了矿产或马拉松赛的痛苦往往被低估了。然而，这两个过程都同样可以被认为是积极的事件，而不是涉及疼痛的大多数。在神经生理层面上，出生和运行马拉松比赛之间的相似之处是催产素系统的特殊参与。由于各种原因，催产素涉及分娩和强烈运动。在劳动期间，催产素介导子宫收缩，而在广泛运行的情况下，它可能涉及维持流体平衡。它还具有良好的记录性镇痛特性，并在记忆形成和召回中起重要作用。有人提出，催产素在恐惧召回期间调节Amygdala（CEA）的中央核的输出。此外，已经证明催产素可以损害恐惧学习，并影响正面和负面情绪阳光刺激的记忆。我们建议以更有利的光线记住疼痛的原因是催产素在杏仁核的中央核中的核心作用，首先在编码阶段。

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