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首页> 外文期刊>BJU international >Vitamin D repletion does not alter urinary calcium excretion in healthy postmenopausal women.
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Vitamin D repletion does not alter urinary calcium excretion in healthy postmenopausal women.

机译：维生素D的补充不会改变健康的绝经后妇女的尿钙排泄。

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OBJECTIVE: To evaluate, in a posthoc analysis of a previous study, whether vitamin D repletion in postmenopausal women with insufficient vitamin D increases urinary calcium excretion, as vitamin D therapy might contribute to hypercalciuria and calcium stones in susceptible individuals, and the effect of vitamin D on the risk of urolithiasis warrants attention. SUBJECTS AND METHODS: We recruited 18 women at > or =5 years after menopause who had vitamin D insufficiency (serum 25(OH)-vitamin D, 16-24 mg/dL). We excluded women with a history of urolithiasis and kidney disease. Women had one calcium absorption study when vitamin D-insufficient, received vitamin D therapy, and completed a second calcium absorption study when vitamin D-replete. We fed subjects meals that mirrored the nutrient composition from self-reported 7-day diet diaries. To measure calcium absorption, we collected urine for 24 h during both visits. RESULTS: We achieved vitamin D repletion in all women (25(OH)-vitamin D before and after treatment, 22 and 63 mg/dL, respectively; P < 0.001). The mean calcium intake was 832 mg/day. Residual urine specimens were available for 16 women, allowing a measurement of 24-h urinary calcium. Calcium excretion did not change after vitamin D therapy (212 before vs 195 mg/day after; P = 0.60). Of four women with hypercalciuria (>247 mg/day), calcium excretion decreased in three (377-312 mg/day, not significant). CONCLUSION: Vitamin D supplementation did not increase the urinary calcium excretion in healthy postmenopausal women. Many stone formers are at risk of premature bone loss, vitamin D insufficiency, or both. Based on the present results we suggest a study of patients with hypercalciuria and nephrolithiasis to determine the risks of vitamin D therapy.
机译：目的：在一项先前研究的事后分析中，评估维生素D不足的绝经后妇女补充维生素D是否会增加尿钙排泄，因为维生素D治疗可能会导致易感人群的钙尿过多和钙结石，以及维生素的作用关于尿路结石风险的D值得关注。受试者和方法：我们招募了绝经后≥5年的18名维生素D功能不全的妇女（血清25（OH）-维生素D，16-24 mg / dL）。我们排除了有尿石症和肾脏疾病史的女性。女性进行了一项维生素D不足时的钙吸收研究，接受了维生素D治疗，并在维生素D充足时完成了第二次钙吸收研究。我们为受试者提供的膳食与自我报告的7天饮食日记中的营养成分相似。为了测量钙的吸收，我们在两次就诊期间收集了24小时的尿液。结果：我们在所有女性中均获得了维生素D的补充（治疗前后分别为25（OH）-维生素D，分别为22和63 mg / dL; P <0.001）。平均钙摄入量为832毫克/天。 16名妇女可使用残留尿液标本，进行24小时尿钙测量。维生素D治疗后钙的排泄没有改变（212毫克vs 195毫克/天; P = 0.60）。在四名高钙尿症（> 247毫克/天）的妇女中，三名钙排泄减少（377-312毫克/天，不显着）。结论：补充维生素D并不能增加绝经后健康女性的尿钙排泄量。许多结石形成者有过早骨质流失，维生素D功能不足或两者兼有的风险。基于目前的结果，我们建议对钙尿过多和肾结石病患者进行研究，以确定维生素D治疗的风险。

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