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首页> 外文期刊>Maternal & child nutrition >The impact of home fortification with multiple micronutrient powder on vitamin A status in young children: A multicenter pragmatic controlled trial in Brazil
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The impact of home fortification with multiple micronutrient powder on vitamin A status in young children: A multicenter pragmatic controlled trial in Brazil

机译：多种微量营养剂对幼儿维生素的影响：巴西的多中心务实对照试验

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Abstract Home fortification with multiple micronutrient powder (MNP) is effective in the prevention of anemia in young children. However, the impact on their vitamin A status remains controversial. This study aimed to evaluate the effect of MNP on vitamin A status in young Brazilian children. A multicenter pragmatic, controlled trial was carried out in primary health centers in four Brazilian cities. In the beginning of the study, the control group (CG) consisted of children 11–14?months old ( n ?=?395) attending in routine pediatric health care. In parallel, the intervention group (IG) was composed of children 6–8?months old ( n ?=?399), in the same health centers, who followed the intervention with MNP for 2–3?months. The analysis of the effect of MNP on vitamin A status was performed by comparing the IG with the CG after a 4‐ to 6‐month follow‐up when IG children had reached the age of the controls. The prevalence of vitamin A deficiency (VAD; serum retinol 0.70?μmol/L) in the CG was 16.2%, while in the IG was 7.5%—a 55% reduction in the VAD [prevalence ratio (95% confidence interval)?=?0.45 (0.28; 0.72)]. This reduction was also significant when stratifying the study centers by coverage of the Brazilian Vitamin A Supplementation Program. The adjusted mean of vitamin A serum concentrations improved in the IG compared with CG children, with a shift to the right in the vitamin A distribution. Home fortification with MNP was effective in reducing VAD among young Brazilian children.
机译：摘要具有多种微量抑制粉末（MNP）的家庭设防在幼儿预防贫血中是有效的。然而，对其维生素的影响成为争议的争议。本研究旨在评估MNP对年轻巴西儿童维生素A状态的影响。在四个巴西城市的主要保健中心进行了多中心务实的受控试验。在研究开始时，对照组（CG）由11-14个月的儿童组成，参加常规儿科医疗保健的数月（n？= 395）。平行，干预组（IG）由6-8名儿童组成，在同一健康中心中的儿童（n？= 399），他们在与MNP的干预中持续2-3个月。通过将Ig与Cg与CG与CG进行比较，当IG儿童达到对照时，通过将Ig与CG进行比较，进行了对维生素A的效果的分析。维生素A缺乏（VAD;血清视黄醇+0.70≤0mol/ L）的患病率为16.2％，而IG中的缺陷为7.5％-A的VAD减少[患病率比（95％置信区间） ？=？0.45（0.28; 0.72）]。当通过覆盖巴西维生素A补充计划来分辨研究中心，这种减少也很显着。与CG儿童相比，IG的维生素血清浓度的调整平均值改善，在维生素A分布的右侧。随着MNP的家庭设防有效减少年轻巴西儿童中的VAD。

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