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首页> 外文期刊>Mediators of inflammation >Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance
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Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance

机译：CMKLR1相对表达和Chemerin血清水平与多糖表型和胰岛素抗性的肥胖症中的相对表达和Chemerin血清水平的反相

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Background. In obesity there is a subclinical chronic low-grade inflammatory response where insulin resistance (IR) may develop. Chemerin is secreted in white adipose tissue and promotes low-grade inflammatory process, where it expressed CMKLR1 receptor. The role of chemerin and CMKLR1 in inflammatory process secondary to obesity is not defined yet. Methods. Cross-sectional study with 134 individuals classified as with and without obesity by body mass index (BMI) and IR. Body fat storage measurements and metabolic and inflammatory markers were measured by routine methods. Soluble chemerin and basal levels of insulin by ELISA and relative expression of CMKLR1 were evaluated with qPCR and 2(-Delta Delta)C(T) method. Results. Differences(P < 0.05) were observed between obesity and lean individuals in body fat storage measurements and metabolic-inflammatory markers. Both CMKLR1 expression and chemerin levels were increased in obesity without IR. Soluble chemerin levels correlate with adiposity and metabolic markers (r = 8.8% to 38.5%), P< 0.05. Conclusion. The increment of CMKLR1 expression was associated with insulin production. Increased serum levels of chemerin in obesity were observed, favoring a dysmetabolic response. The results observed in this study suggest that both chemerin and CMKLR1 have opposite expression in the context of low-grade inflammatory response manifested in the development of IR.
机译：背景。在肥胖症中，存在亚临床慢性低级炎症反应，其中胰岛素抵抗（IR）可能发生。 Chemerin在白色脂肪组织中分泌，促进低级炎症过程，在那里表达CMKLR1受体。 Chemerin和CMKLR1在肥胖的炎症过程中的作用尚未定义。方法。用体重指数（BMI）和IR的横截面研究分类为和不肥胖的肥胖。通过常规方法测量体脂储存测量和代谢和炎症标记。用QPCR和2（-Delta delta）C（T）方法评价ELISA和CMKLR1的相对表达的胰岛素和基础水平。结果。在体脂储存测量和代谢炎症标志物之间观察到肥胖症和瘦症之间观察到差异（P <0.05）。在没有IR的肥胖症中，CMKLR1表达和Chemerin水平均增加。可溶性培养素水平与肥胖和代谢标志物相关（r = 8.8％至38.5％），P <0.05。结论。 CMKLR1表达的增量与胰岛素产生有关。观察到肥胖症中的血清血清水平增加，有利于具有多良同种异体响应。本研究中观察到的结果表明，在IR的开发中表现出低级炎症反应的情况下，Chemerin和CMKLR1都表达了相反的表达。

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